Shabondama Soap Co., Ltd., Kitakyushu 808-0195, Japan.
Department of Microbiology, University of Occupational and Environmental Health, Kitakyushu 807-0804, Japan.
Int J Mol Sci. 2019 Jan 14;20(2):312. doi: 10.3390/ijms20020312.
Wounds frequently become infected or contaminated with bacteria. Potassium oleate (C18:1K), a type of fatty acid potassium, caused >4 log colony-forming unit (CFU)/mL reductions in the numbers of and within 10 min and a >2 log CFU/mL reduction in the number of within 1 min. C18:1K (proportion removed: 90.3%) was significantly more effective at removing biofilms than the synthetic surfactant detergents sodium lauryl ether sulfate (SLES) (74.8%, < 0.01) and sodium lauryl sulfate (SLS) (78.0%, < 0.05). In the WST (water-soluble tetrazolium) assay, mouse fibroblasts (BALB/3T3 clone A31) in C18:1K (relative viability vs. control: 102.8%) demonstrated a significantly higher viability than those in SLES (30.1%) or SLS (18.1%, < 0.05). In a lactate dehydrogenase (LDH) leakage assay, C18:1K (relative leakage vs. control: 108.9%) was found to be associated with a significantly lower LDH leakage from mouse fibroblasts than SLES or SLS (720.6% and 523.4%, respectively; < 0.05). Potassium oleate demonstrated bactericidal effects against various species including , and ; removed significantly greater amounts of biofilm material than SLES and SLS; and maintained fibroblast viability; therefore, it might be useful for wound cleaning and peri-wound skin.
伤口经常会感染或被细菌污染。油酸钾（C18:1K），一种脂肪酸钾，在 10 分钟内使 和 减少超过 4 个对数集落形成单位（CFU）/mL，在 1 分钟内使 减少超过 2 个对数 CFU/mL。C18:1K（去除比例：90.3%）在去除生物膜方面比合成表面活性剂清洁剂月桂醚硫酸酯（SLES）（74.8%， < 0.01）和十二烷基硫酸钠（SLS）（78.0%， < 0.05）更有效。在 WST（水溶性四唑）测定中，C18:1K 中的小鼠成纤维细胞（BALB/3T3 克隆 A31）（相对活力与对照相比：102.8%）显示出比 SLES（30.1%）或 SLS（18.1%， < 0.05）更高的活力。在乳酸脱氢酶（LDH）渗漏测定中，C18:1K（相对渗漏与对照相比：108.9%）与从小鼠成纤维细胞中漏出的 LDH 明显低于 SLES 或 SLS（分别为 720.6%和 523.4%； < 0.05）相关。油酸钾对包括 、 和 在内的各种物种具有杀菌作用；去除的 生物膜材料明显多于 SLES 和 SLS；并保持成纤维细胞活力；因此，它可能对伤口清洁和周围皮肤有用。
