Shallcross Laura J, Hayward Andrew C, Johnson Anne M, Petersen Irene
Research Department of Infection and Population Health.
Research Department of Infection and Population Health;
Br J Gen Pract. 2015 Oct;65(639):e668-76. doi: 10.3399/bjgp15X686929.
Boils and abscesses are common in primary care but the burden of recurrent infection is unknown.
To investigate the incidence of and risk factors for recurrence of boil or abscess for individuals consulting primary care.
Cohort study using electronic health records from primary care in the UK.
The Health Improvement Network (THIN) database was used to identify patients who had consulted their GP for a boil or abscess. Poisson regression was used to examine the relationship between age, sex, social deprivation, and consultation and to calculate the incidence of, and risk factors for, repeat consultation for a boil or abscess.
Overall, 164 461 individuals were identified who consulted their GP for a boil or abscess between 1995 and 2010. The incidence of first consultation for a boil or abscess was 512 (95% CI = 509 to 515) per 100 000 person-years in females and 387 (95% CI = 385 to 390) per 100 000 person-years in males. First consultations were most frequent in younger age groups (16-34 years) and those with the greatest levels of social deprivation. The rate of repeat consultation for a new infection during follow up was 107.5 (95% confidence interval [CI] = 105.6 to 109.4) per 1000 person-years. Obesity (relative risk [RR] 1.3, 95% CI = 1.2 to 1.3), diabetes (RR 1.3, 95% CI = 1.2 to 1.3), smoking (RR 1.3, 95% CI = 1.2 to 1.4), age <30 years (RR 1.2, 95% CI = 1.2 to 1.3), and prior antibiotic use (RR 1.4, 95% CI = 1.3-1.4) were all associated with repeat consultation for a boil or abscess.
Ten percent of patients with a boil or abscess develop a repeat boil or abscess within 12 months. Obesity, diabetes, young age, smoking, and prescription of an antibiotic in the 6 months before initial presentation were independently associated with recurrent infection, and may represent options for prevention.
疖肿和脓肿在初级保健中很常见,但反复感染的负担尚不清楚。
调查因疖肿或脓肿就诊于初级保健机构的个体中疖肿或脓肿复发的发生率及危险因素。
使用英国初级保健机构电子健康记录进行的队列研究。
利用健康改善网络(THIN)数据库识别因疖肿或脓肿就诊于全科医生(GP)的患者。采用泊松回归分析年龄、性别、社会剥夺程度与就诊之间的关系,并计算疖肿或脓肿再次就诊的发生率及危险因素。
总体而言,在1995年至2010年间,共识别出164461名因疖肿或脓肿就诊于全科医生的个体。女性因疖肿或脓肿首次就诊的发生率为每10万人年512例(95%置信区间[CI]=509至515),男性为每10万人年387例(95%CI=385至390)。首次就诊在较年轻年龄组(16 - 34岁)和社会剥夺程度最高的人群中最为常见。随访期间新发感染的再次就诊率为每1000人年107.5例(95%置信区间[CI]=105.6至109.4)。肥胖(相对危险度[RR]1.3,95%CI=1.2至1.3)、糖尿病(RR 1.3,95%CI=1.2至1.3)、吸烟(RR 1.3,95%CI=1.2至1.4)、年龄<30岁(RR 1.2,95%CI=1.2至1.3)以及之前使用过抗生素(RR 1.4,95%CI=1.3 - 1.4)均与疖肿或脓肿的再次就诊相关。
10%的疖肿或脓肿患者在12个月内会再次出现疖肿或脓肿。肥胖、糖尿病、年轻、吸烟以及初次就诊前6个月内使用抗生素与反复感染独立相关,可能是预防的选择。