Nagendran Vasantha, Emmanuel Noel, Bansal Amolak S
Epsom and St Helier University Hospitals NHS Trust, Carshalton, Surrey SM5 1AA, UK ; St Georges University of London, London SW17 0RE, UK.
St George's University Hospitals NHS Foundation Trust, Tooting, London SW17 0QT, UK.
Case Reports Immunol. 2015;2015:286380. doi: 10.1155/2015/286380. Epub 2015 Aug 27.
Purpose. To find out if the serum IgG level in the newborn baby was affected by low maternal serum IgG during pregnancy in two newly diagnosed primary antibody deficient patients. Method. Infant cord blood IgG level was compared with maternal IgG level in 2 mothers with newly diagnosed primary antibody deficiency, who declined replacement IgG treatment during pregnancy. Results. Both mothers delivered healthy babies with normal IgG levels at birth. Conclusions. The normal IgG levels and sound health in these 2 babies in spite of low maternal IgG throughout pregnancy raise interesting discussion points about maternofoetal immunoglobulin transport mechanisms in primary antibody deficiency.
目的。在两名新诊断的原发性抗体缺陷患者中，探究孕期母亲血清IgG水平低是否会影响新生儿的血清IgG水平。方法。比较2名新诊断为原发性抗体缺陷且孕期拒绝接受IgG替代治疗的母亲的婴儿脐带血IgG水平与母亲的IgG水平。结果。两名母亲均分娩出出生时IgG水平正常的健康婴儿。结论。尽管这两名婴儿在整个孕期母亲的IgG水平较低，但他们的IgG水平正常且健康状况良好，这引发了关于原发性抗体缺陷中母胎免疫球蛋白转运机制的有趣讨论点。
