Fälth-Magnusson K, Kjellman N I, Magnusson K E
Department of Pediatrics, Faculty of Health Sciences, University of Linköping, Sweden.
J Allergy Clin Immunol. 1988 Apr;81(4):743-9. doi: 10.1016/0091-6749(88)91048-2.
Serum levels of IgG, IgA, and IgM antibodies against ovalbumin, beta-lactoglobulin, and gliadin were measured in a series of 210 "allergy-risk" infants and their mothers. The antibody levels were determined with ELISA in sera obtained from mothers at delivery, and from their babies at birth, 6 weeks, 6 months, and 18 months. High levels of maternal IgG, IgA, or IgM antibodies to food at delivery did not appear to protect the baby against development of atopic disease. Maternal avoidance of cow's milk and egg during pregnancy had no significant influence on the level of food antibodies in cord blood, but the mother's intake of these foods during lactation affected the immunologic response of the baby, not only to these antigens but also to gliadin as well. Babies with minimal cow's milk exposure before 6 months had significantly lower levels of IgG to beta-lactoglobulin than babies regularly exposed to cow's milk. We conclude that maternal elimination diet during lactation influences the immunologic response of the baby, but if this prevents the development of atopic disease or just delays the immunologic maturation remains to be evaluated.
在一系列210名“过敏风险”婴儿及其母亲中，检测了针对卵清蛋白、β-乳球蛋白和麦醇溶蛋白的IgG、IgA和IgM抗体的血清水平。通过ELISA测定了分娩时母亲以及其婴儿出生时、6周、6个月和18个月时血清中的抗体水平。分娩时母亲针对食物的高水平IgG、IgA或IgM抗体似乎并不能保护婴儿免于患特应性疾病。孕期母亲避免食用牛奶和鸡蛋对脐带血中食物抗体水平没有显著影响，但母亲在哺乳期摄入这些食物会影响婴儿的免疫反应，不仅针对这些抗原，还针对麦醇溶蛋白。6个月前牛奶接触极少的婴儿，其针对β-乳球蛋白的IgG水平明显低于经常接触牛奶的婴儿。我们得出结论，哺乳期母亲的排除饮食会影响婴儿的免疫反应，但这是否能预防特应性疾病的发生或只是延迟免疫成熟，仍有待评估。
