胃食管反流所致难治性慢性咳嗽：定义、机制与管理
Refractory chronic cough due to gastroesophageal reflux: Definition, mechanism and management.
作者信息
Lv Han-Jing, Qiu Zhong-Min
机构信息
Han-Jing Lv, Zhong-Min Qiu, Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
出版信息
World J Methodol. 2015 Sep 26;5(3):149-56. doi: 10.5662/wjm.v5.i3.149.
Abstract
Refractory chronic cough due to gastroesophageal reflux is a troublesome condition unresponsive to the standard medical anti-reflux therapy. Its underlying mechanisms may include incomplete acid suppression, non-acid reflux, transient lower esophageal sphincter relaxations and esophageal hypersensitivity. The diagnosis of this disorder depends on both the findings of multi-channel intraluminal impedance-pH monitoring and the subsequent intensified anti-reflux therapy. The strategies of pharmacological treatment for refractory chronic cough due to reflux include the optimization of proton pump inhibitors and add-on therapies with histamine H2 receptor antagonists, baclofen and gabapentin. However, the further study is needed to satisfy its management.
摘要
胃食管反流所致难治性慢性咳嗽是一种麻烦的病症，对标准的抗反流药物治疗无反应。其潜在机制可能包括抑酸不完全、非酸性反流、食管下括约肌短暂松弛和食管高敏反应。这种疾病的诊断取决于多通道腔内阻抗-pH监测结果及随后的强化抗反流治疗。反流所致难治性慢性咳嗽的药物治疗策略包括优化质子泵抑制剂以及加用组胺H2受体拮抗剂、巴氯芬和加巴喷丁进行治疗。然而，仍需要进一步研究以完善其治疗。
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