Fan Ling-Yun, Sun Yu, Lee Huey-Jane, Yang Shu-Chien, Chen Ta-Fu, Lin Ker-Neng, Lin Chung-Chi, Wang Pei-Ning, Tang Li-Yu, Chiu Ming-Jang
Department of Neurology, En Chu Kong Hospital, New Taipei City, Taiwan; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
Department of Neurology, En Chu Kong Hospital, New Taipei City, Taiwan.
PLoS One. 2015 Sep 28;10(9):e0139154. doi: 10.1371/journal.pone.0139154. eCollection 2015.
Evidence of an association between lifestyle and marital status and risk of dementia is limited in Asia.
In this nationwide population-based cross-sectional survey, participants were selected by computerized random sampling from all 19 counties in Taiwan. A total of 10432 residents were assessed by a door-to-door in-person survey, among whom 7035 were normal and 929 were diagnosed with dementia using the criteria recommended by National Institute on Aging-Alzheimer's Association. Premorbid lifestyle habits and demographic data including marital status were compared between normal subjects and participants with dementia.
After adjustment for age, gender, education, body mass index, smoking, drinking, marital status, sleep habits, exercise, social engagement and co-morbidities including hypertension, diabetes and cerebrovascular diseases, an increased risk for dementia was found in people with widow or widower status (OR 1.42, 95% CI 1.15-1.77) and people who used to take a nap in the afternoon (OR 1.33, 95% CI 1.02-1.72). Decreased risk was found in people with the habit of regular exercise (OR 0.12, 95% CI 0.09-0.16), adequate night sleep (OR 0.55, 95% CI 0.39-0.76) and regular social engagement (OR 0.53, 95% CI 0.36-0.77).
Our results provide preliminary evidence of possible risk-reduction effects for dementia, including regular exercise even in modest amounts, social engagement and adequate night sleep, whereas people with the widow/widower status or who used to take an afternoon nap might have increased risk of dementia.
在亚洲,生活方式、婚姻状况与痴呆症风险之间关联的证据有限。
在这项基于全国人口的横断面调查中,通过计算机随机抽样从台湾所有19个县选取参与者。共有10432名居民接受了上门面对面调查,其中7035名正常,929名根据美国国立衰老研究所-阿尔茨海默病协会推荐的标准被诊断为痴呆症。比较了正常受试者与痴呆症患者的病前生活习惯和包括婚姻状况在内的人口统计学数据。
在调整年龄、性别、教育程度、体重指数、吸烟、饮酒、婚姻状况、睡眠习惯、运动、社交活动以及包括高血压、糖尿病和脑血管疾病在内的合并症后,发现丧偶者(比值比1.42,95%置信区间1.15 - 1.77)以及过去有午睡习惯的人(比值比1.33,95%置信区间1.02 - 1.72)患痴呆症的风险增加。发现有规律运动习惯的人(比值比0.12,95%置信区间0.09 - 0.16)、夜间睡眠充足的人(比值比0.55,95%置信区间0.39 - 0.76)和有规律社交活动的人(比值比0.53,95%置信区间0.36 - 0.77)患痴呆症的风险降低。
我们的结果为痴呆症可能的风险降低效应提供了初步证据,包括即使是适度的规律运动、社交活动和充足的夜间睡眠,而丧偶者或过去有午睡习惯的人患痴呆症的风险可能会增加。