Sun Yu, Lee Huey-Jane, Yang Shu-Chien, Chen Ta-Fu, Lin Ker-Neng, Lin Chung-Chih, Wang Pei-Ning, Tang Li-Yu, Chiu Ming-Jang
Department of Neurology, En Chu Kong Hospital, New Taipei City, Taiwan; Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
Taiwan Alzheimer's Disease Association, Taipei, Taiwan.
PLoS One. 2014 Jun 18;9(6):e100303. doi: 10.1371/journal.pone.0100303. eCollection 2014.
An increasing population of dementia patients produces substantial societal impacts. We assessed the prevalence of mild cognitive impairment (MCI) and all-cause dementia, including very mild dementia (VMD), in Taiwan. In a nationwide population-based cross-sectional survey, participants were selected by computerized random sampling from all 19 Taiwan counties and were enrolled between December 2011 and March 2013. Cases were identified through in-person interviews based on the National Institute on Aging-Alzheimer's Association clinical criteria. Demographic data and histories involving mental status and function in daily living were collected. The principal objective assessments were the Taiwanese Mental Status Examination and Clinical Dementia Rating. In all, 10,432 people aged 65 years or older (mean age 76.2 ± 6.7, 52.3% women) were interviewed. The age-adjusted prevalence of all-cause dementia was 8.04% (95% CI 7.47-8.61), including a 3.25% (95% CI 2.89-3.61) prevalence of VMD; that of MCI was 18.76% (95% CI 17.91-19.61). Women had a higher prevalence than men of both all-cause dementia (9.71% vs. 6.36%) and MCI (21.63% vs. 15.57%). MCI affects a considerable portion of the population aged 65 and above in Taiwan. The inclusion of VMD yields dementia prevalence rates higher than those previously reported from Taiwan. Old age, female gender, and a low educational level are significant associated factors.
痴呆症患者数量的不断增加对社会产生了重大影响。我们评估了台湾轻度认知障碍(MCI)和全因性痴呆(包括极轻度痴呆,VMD)的患病率。在一项基于全国人口的横断面调查中,通过计算机随机抽样从台湾所有19个县中选取参与者,并于2011年12月至2013年3月期间纳入研究。根据美国国立衰老研究所-阿尔茨海默病协会的临床标准,通过面对面访谈确定病例。收集了人口统计学数据以及涉及精神状态和日常生活功能的病史。主要的客观评估是台湾精神状态检查和临床痴呆评定量表。总共对10432名65岁及以上的人(平均年龄76.2±6.7岁,女性占52.3%)进行了访谈。全因性痴呆的年龄调整患病率为8.04%(95%置信区间7.47 - 8.61),其中VMD的患病率为3.25%(95%置信区间2.89 - 3.61);MCI的患病率为18.76%(95%置信区间17.91 - 19.61)。全因性痴呆(9.71%对6.36%)和MCI(21.63%对15.57%)的患病率女性均高于男性。MCI影响了台湾相当一部分65岁及以上的人群。纳入VMD后,痴呆症患病率高于台湾此前报告的患病率。老年、女性性别和低教育水平是显著的相关因素。