Stack A, Manolis A J, Ritz E
a a University Hospital Limerick, Graduate Entry Medical School, University of Limerick , Ireland.
b b Cardiology Dept , Asklepeion General Hospital , Athens , Greece.
Curr Med Res Opin. 2015;31 Suppl 2:21-6. doi: 10.1185/03007995.2015.1087984.
A bulk of evidence now exists that links gout with adverse cardiovascular (CV) outcomes. However, continuing doubt remains as to whether hyperuricemia can be truly considered an independent major CV risk factor. In fact, many gouty patients who develop major CV and renal events also possess several traditional CV risk factors, the presence of which can potentially confound any relationship between gout and adverse CV events. This paper reviews the available evidence to determine whether sufficient proof exists from biological, epidemiological and clinical trial studies to support a causal relationship between gout and major CV and renal events. This review is based on a PubMed/Embase database search for articles on hyperuricemia and its impact on cardiovascular and renal function.
目前有大量证据表明痛风与不良心血管（CV）结局相关。然而，高尿酸血症是否真的可被视为独立的主要CV危险因素仍存在持续的疑问。事实上，许多发生主要CV和肾脏事件的痛风患者也存在多种传统CV危险因素，这些因素的存在可能会混淆痛风与不良CV事件之间的任何关系。本文回顾现有证据，以确定生物学、流行病学和临床试验研究中是否存在充分证据支持痛风与主要CV和肾脏事件之间的因果关系。本综述基于对PubMed/Embase数据库中关于高尿酸血症及其对心血管和肾功能影响的文章的检索。
