Tran-Gia Johannes, Lohr David, Weng Andreas Max, Ritter Christian Oliver, Stäb Daniel, Bley Thorsten Alexander, Köstler Herbert
Department of Diagnostic and Interventional Radiology, University of Würzburg, Germany.
Department of Nuclear Medicine, University of Würzburg, Germany.
Magn Reson Med. 2016 Sep;76(3):880-7. doi: 10.1002/mrm.25921. Epub 2015 Sep 28.
To reduce saturation effects in the arterial input function (AIF) estimation of quantitative myocardial first-pass saturation recovery perfusion imaging by employing a model-based reconstruction.
Imaging was performed with a saturation recovery prepared radial FLASH sequence. A model-based reconstruction was applied for reconstruction. By exploiting prior knowledge about the relaxation process, an image series with different saturation recovery times was reconstructed. By evaluating images with an effective saturation time of approximately 3 ms, saturation effects in the AIF determination were reduced. In a volunteer study, this approach was compared with a standard prebolus technique.
In comparison to the low-dose injection of a prebolus acquisition, saturation effects were further reduced in the AIFs determined using the model-based approach. These effects, which were clearly visible for all six volunteers, were reflected in a statistically significant difference of up to 20% in the absolute perfusion values.
The application of model-based reconstruction algorithms in quantitative myocardial perfusion imaging promises a significant improvement of the AIF determination. In addition to greatly reducing saturation effects that occur even for the prebolus methods, only a single bolus has to be applied. Magn Reson Med 76:880-887, 2016. © 2015 Wiley Periodicals, Inc.
通过采用基于模型的重建方法，减少定量心肌首过饱和恢复灌注成像的动脉输入函数（AIF）估计中的饱和效应。
采用饱和恢复准备的径向FLASH序列进行成像。应用基于模型的重建方法进行重建。通过利用关于弛豫过程的先验知识，重建具有不同饱和恢复时间的图像序列。通过评估有效饱和时间约为3 ms的图像，减少了AIF测定中的饱和效应。在一项志愿者研究中，将该方法与标准预注射技术进行了比较。
与预注射采集的低剂量注射相比，使用基于模型的方法确定的AIF中的饱和效应进一步降低。所有六名志愿者都明显可见这些效应，这在绝对灌注值上反映出高达20%的统计学显著差异。
基于模型的重建算法在定量心肌灌注成像中的应用有望显著改善AIF的测定。除了大大减少即使在预注射方法中也会出现的饱和效应外，只需注射一次团注。《磁共振医学》76:880 - 887，2016年。© 2015威利期刊公司。
