Köstler Herbert, Ritter Christian, Lipp Michael, Beer Meinrad, Hahn Dietbert, Sandstede Jörn
Institut für Röntgendiagnostik, Universität Würzburg, Germany.
Magn Reson Med. 2004 Aug;52(2):296-9. doi: 10.1002/mrm.20160.
The purpose of this study was to present the prebolus technique for quantitative multislice myocardial perfusion imaging. In quantitative MR perfusion studies the maximum contrast agent dose is limited by the requirement to determine the arterial input function (AIF). The prebolus technique consists of two consecutive contrast agent administrations. The AIF is determined from a first low-dose bolus, while a second, high-dose bolus allows the measurement of the myocardium with improved signal increase. The results of the prebolus technique using a multislice saturation recovery trueFISP sequence in healthy volunteers are presented. In comparison to a standard dose of 3 ml Gd-DTPA, perfusion values are maintained while the signal increase in the concentration time courses was considerably improved, accompanied by reduced standard deviations of the obtained perfusion values (0.72 +/- 0.13 ml/g/min for 1 ml/8 ml and 0.67 +/- 0.10 ml/g/min for 1 ml/12 ml Gd-DTPA, respectively).
本研究的目的是介绍用于定量多层心肌灌注成像的预注射技术。在定量磁共振灌注研究中，最大造影剂剂量受到确定动脉输入函数（AIF）的要求的限制。预注射技术包括连续两次注射造影剂。通过第一次低剂量注射确定AIF，而第二次高剂量注射则可在信号增强改善的情况下测量心肌。本文展示了在健康志愿者中使用多层饱和恢复trueFISP序列的预注射技术的结果。与3 ml钆喷酸葡胺的标准剂量相比，灌注值得以维持，同时浓度-时间曲线中的信号增强得到显著改善，所获得的灌注值的标准差也有所降低（分别为1 ml/8 ml钆喷酸葡胺时0.72±0.13 ml/g/min和1 ml/12 ml钆喷酸葡胺时0.67±0.10 ml/g/min）。
