副肿瘤性小脑变性中的快速眼动睡眠行为障碍：免疫治疗后改善
Rapid Eye Movement Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy.
作者信息
Vale Thiago Cardoso, Fernandes do Prado Lucila Bizari, do Prado Gilmar Fernandes, Povoas Barsottini Orlando Graziani, Pedroso José Luiz
机构信息
Movement Disorders Unit, Neurology Service, University Hospital. Department of Internal Medicine, Faculty of Medicine, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil.
Division of General Neurology and Ataxia Unit, Department of Neurology, Universidade Federal São Paulo, São Paulo, Brazil.
出版信息
Sleep. 2016 Jan 1;39(1):117-20. doi: 10.5665/sleep.5330.
Abstract
STUDY OBJECTIVES
To report two female patients with paraneoplastic cerebellar degeneration (PCD) related to breast cancer that presented with rapid eye movement-sleep behavior disorder (RBD) and improved sleep symptoms with immunotherapy.
METHODS
The two patients were evaluated through clinical scale and polysomnography before and after therapy with intravenous immunoglobulin.
RESULTS
RBD was successfully treated with immunotherapy in both patients. Score on the RBD screening questionnaire dropped from 10 to 1 or 0, allied with the normalization of polysomnographic findings.
CONCLUSIONS
A marked improvement in RBD after immunotherapy in PCD raises the hypothesis that secondary RBD may be an immune-mediated sleep disorder.
摘要
研究目的
报告两例与乳腺癌相关的副肿瘤性小脑变性（PCD）女性患者，她们表现出快速眼动睡眠行为障碍（RBD），且免疫治疗后睡眠症状改善。
方法
在静脉注射免疫球蛋白治疗前后，通过临床量表和多导睡眠图对这两名患者进行评估。
结果
两名患者的RBD均通过免疫治疗成功治愈。RBD筛查问卷评分从10降至1或0，同时多导睡眠图检查结果恢复正常。
结论
PCD患者免疫治疗后RBD明显改善，这提示继发性RBD可能是一种免疫介导的睡眠障碍。
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本文引用的文献
1
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Mov Disord. 2015 Apr 15;30(5):614-23. doi: 10.1002/mds.26158. Epub 2015 Mar 11.
2
A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study.一种新型非快速眼动和快速眼动睡眠障碍相关呼吸暂停与 IgLON5 抗体相关：病例系列、抗原特征和尸检研究。
Lancet Neurol. 2014 Jun;13(6):575-86. doi: 10.1016/S1474-4422(14)70051-1. Epub 2014 Apr 3.
3
Secondary ''incidental'' REM sleep behavior disorder: do we ever think of it?继发性“偶发”快速眼动期睡眠行为障碍：我们是否曾考虑过？
Sleep Med. 2011 Dec;12 Suppl 2:S50-3. doi: 10.1016/j.sleep.2011.10.011.
4
Sleep disorders in cerebellar ataxias.小脑性共济失调中的睡眠障碍
Arq Neuropsiquiatr. 2011 Apr;69(2A):253-7. doi: 10.1590/s0004-282x2011000200021.
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Narcolepsy, REM sleep behavior disorder, and supranuclear gaze palsy associated with Ma1 and Ma2 antibodies and tonsillar carcinoma.发作性睡病、快速眼动睡眠行为障碍及与Ma1和Ma2抗体以及扁桃体癌相关的核上性凝视麻痹。
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6
Translation and validation into Brazilian version of the Scale of the Assessment and Rating of Ataxia (SARA).将共济失调评估与分级量表（SARA）翻译成巴西版本并进行验证。
Arq Neuropsiquiatr. 2010 Apr;68(2):228-30. doi: 10.1590/s0004-282x2010000200014.
7
Paraneoplastic movement disorders.副肿瘤性运动障碍
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8
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9
Rapid-eye-movement sleep behavior disorder secondary to acute aseptic limbic encephalitis.急性无菌性边缘叶脑炎继发快速眼动睡眠行为障碍
J Neurol. 2009 Jul;256(7):1174-6. doi: 10.1007/s00415-009-5067-9. Epub 2009 Feb 25.
10
Paraneoplastic neurological syndromes: a review.副肿瘤性神经系统综合征：综述
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