小儿急性起病神经精神综合征（PANS）患儿的快速眼动睡眠异常
Rapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).
作者信息
Gaughan Thomas, Buckley Ashura, Hommer Rebecca, Grant Paul, Williams Kyle, Leckman James F, Swedo Susan E
机构信息
Department of Pediatrics and Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD.
Pediatric Neuropsychiatry and Immunology Program, Massachusetts General Hospital, Harvard University School of Medicine, Boston, MA.
出版信息
J Clin Sleep Med. 2016 Jul 15;12(7):1027-32. doi: 10.5664/jcsm.5942.
Abstract
STUDY OBJECTIVES
Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS).
METHODS
Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3-10 y) underwent single-night full polysomnography (PSG) read by a pediatric neurologist.
RESULTS
Thirteen of 15 subjects (87%) had abnormalities detected with PSG. Twelve of 15 had evidence of rapid eye movement (REM) sleep motor disinhibition, as characterized by excessive movement, laughing, hand stereotypies, moaning, or the continuation of periodic limb movements during sleep (PLMS) into REM sleep.
CONCLUSIONS
This study shows various forms of REM sleep motor disinhibition present in a population of children with PANS.
摘要
研究目的
对患有儿童急性起病神经精神综合征（PANS）的儿童进行睡眠结构的多导睡眠图调查。
方法
连续15名符合PANS标准的受试者（平均年龄 = 7.2岁；范围3 - 10岁）接受了由儿科神经科医生解读的单夜全多导睡眠图（PSG）检查。
结果
15名受试者中有13名（87%）通过PSG检测出异常。15名中有12名有快速眼动（REM）睡眠运动脱抑制的证据，其特征为过度运动、大笑、手部刻板动作、呻吟，或睡眠期间周期性肢体运动（PLMS）延续至REM睡眠。
结论
本研究显示在患有PANS的儿童群体中存在各种形式的REM睡眠运动脱抑制。
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