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Rapid Eye Movement Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy.副肿瘤性小脑变性中的快速眼动睡眠行为障碍：免疫治疗后改善
Sleep. 2016 Jan 1;39(1):117-20. doi: 10.5665/sleep.5330.
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Rapid Eye Movement Sleep Behavior Disorder During Childhood.儿童期快速眼动睡眠行为障碍
Sleep Med Clin. 2015 Jun;10(2):163-7. doi: 10.1016/j.jsmc.2015.02.004. Epub 2015 Mar 12.
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Sleep in Children and Adolescents with Obsessive-Compulsive Disorder.患有强迫症的儿童和青少年的睡眠情况
Sleep Med Clin. 2015 Jun;10(2):133-41. doi: 10.1016/j.jsmc.2015.02.006. Epub 2015 Mar 18.
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Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): recommendations from the 2013 PANS Consensus Conference.儿童急性起病神经精神综合征（PANS）青少年的临床评估：2013年PANS共识会议的建议
J Child Adolesc Psychopharmacol. 2015 Feb;25(1):3-13. doi: 10.1089/cap.2014.0084. Epub 2014 Oct 17.
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A relationship between REM sleep measures and the duration of posttraumatic stress disorder in a young adult urban minority population.年轻成年城市少数族裔人群中快速眼动睡眠指标与创伤后应激障碍持续时间的关系。
Sleep. 2014 Aug 1;37(8):1321-6. doi: 10.5665/sleep.3922.
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Quantitative analyses of REM sleep without atonia in children and adolescents with REM sleep behavior disorder.
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Evaluation of incidence and clinical features of antibody-associated autoimmune encephalitis mimicking dementia.评估以痴呆为表现的抗体相关自身免疫性脑炎的发病率和临床特征。
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Polysomnographic features of early-onset depression: a meta-analysis.早发性抑郁症的多导睡眠图特征：一项荟萃分析。
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Emerging therapeutics in sleep.睡眠领域的新兴治疗方法。
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Rapid eye movement sleep behavior disorder and rapid eye movement sleep without atonia in narcolepsy.发作性睡病中的快速眼动睡眠行为障碍和快速动眼睡眠无张力。
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小儿急性起病神经精神综合征（PANS）患儿的快速眼动睡眠异常

Rapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).

作者信息

Gaughan Thomas, Buckley Ashura, Hommer Rebecca, Grant Paul, Williams Kyle, Leckman James F, Swedo Susan E

机构信息

Department of Pediatrics and Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD.

Pediatric Neuropsychiatry and Immunology Program, Massachusetts General Hospital, Harvard University School of Medicine, Boston, MA.

出版信息

J Clin Sleep Med. 2016 Jul 15;12(7):1027-32. doi: 10.5664/jcsm.5942.

DOI:10.5664/jcsm.5942
PMID:27166296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4918985/
Abstract

STUDY OBJECTIVES

Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS).

METHODS

Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3-10 y) underwent single-night full polysomnography (PSG) read by a pediatric neurologist.

RESULTS

Thirteen of 15 subjects (87%) had abnormalities detected with PSG. Twelve of 15 had evidence of rapid eye movement (REM) sleep motor disinhibition, as characterized by excessive movement, laughing, hand stereotypies, moaning, or the continuation of periodic limb movements during sleep (PLMS) into REM sleep.

CONCLUSIONS

This study shows various forms of REM sleep motor disinhibition present in a population of children with PANS.

摘要

研究目的

对患有儿童急性起病神经精神综合征（PANS）的儿童进行睡眠结构的多导睡眠图调查。

方法

连续15名符合PANS标准的受试者（平均年龄 = 7.2岁；范围3 - 10岁）接受了由儿科神经科医生解读的单夜全多导睡眠图（PSG）检查。

结果

15名受试者中有13名（87%）通过PSG检测出异常。15名中有12名有快速眼动（REM）睡眠运动脱抑制的证据，其特征为过度运动、大笑、手部刻板动作、呻吟，或睡眠期间周期性肢体运动（PLMS）延续至REM睡眠。

结论

本研究显示在患有PANS的儿童群体中存在各种形式的REM睡眠运动脱抑制。