• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在检测全球收集的15377株临床菌株时，黏菌素和多黏菌素B在效力和分类一致性方面的差异。

Differences in potency and categorical agreement between colistin and polymyxin B when testing 15,377 clinical strains collected worldwide.

作者信息

Sader Helio S, Rhomberg Paul R, Farrell David J, Jones Ronald N

机构信息

JMI Laboratories, North Liberty, IA, USA.

JMI Laboratories, North Liberty, IA, USA.

出版信息

Diagn Microbiol Infect Dis. 2015 Dec;83(4):379-81. doi: 10.1016/j.diagmicrobio.2015.08.013. Epub 2015 Aug 28.

DOI:10.1016/j.diagmicrobio.2015.08.013
PMID:26415906
Abstract

Gram-negative bacilli (n=15,377) were tested against colistin (polymyxin E) and polymyxin B by a commercial broth microdilution method (Sensititre®). Among Pseudomonas aeruginosa and Acinetobacter spp., colistin and polymyxin B MIC values were within ±1 doubling dilution for >99.0% of strains. Among Klebsiella spp. and Escherichia coli, 55.0 and 53.2% of strains displayed a colistin MIC 2-fold lower than polymyxin B, but polymyxin B was slightly more potent than colistin against strains with decreased susceptibility to either polymyxin.

摘要

采用商业肉汤微量稀释法（Sensititre®）对15377株革兰氏阴性杆菌进行了针对黏菌素（多黏菌素E）和多黏菌素B的检测。在铜绿假单胞菌和不动杆菌属中，对于超过99.0%的菌株，黏菌素和多黏菌素B的最低抑菌浓度（MIC）值在±1倍稀释范围内。在克雷伯菌属和大肠杆菌中，分别有55.0%和53.2%的菌株对黏菌素的MIC值比多黏菌素B低2倍，但对于对这两种多黏菌素敏感性降低的菌株，多黏菌素B的效力略强于黏菌素。

相似文献

1
Differences in potency and categorical agreement between colistin and polymyxin B when testing 15,377 clinical strains collected worldwide.在检测全球收集的15377株临床菌株时，黏菌素和多黏菌素B在效力和分类一致性方面的差异。
Diagn Microbiol Infect Dis. 2015 Dec;83(4):379-81. doi: 10.1016/j.diagmicrobio.2015.08.013. Epub 2015 Aug 28.
2
Contemporary assessment of antimicrobial susceptibility testing methods for polymyxin B and colistin: review of available interpretative criteria and quality control guidelines.多粘菌素B和黏菌素抗菌药物敏感性试验方法的当代评估：现有解释标准和质量控制指南综述
J Clin Microbiol. 2001 Jan;39(1):183-90. doi: 10.1128/JCM.39.1.183-190.2001.
3
Contemporary activity of colistin and polymyxin B against a worldwide collection of Gram-negative pathogens: results from the SENTRY Antimicrobial Surveillance Program (2006-09).替加环素和黏菌素对来自全球范围内革兰氏阴性病原体的最新活性：SENTRY 抗菌药物监测计划（2006-09 年）的结果。
J Antimicrob Chemother. 2011 Sep;66(9):2070-4. doi: 10.1093/jac/dkr239. Epub 2011 Jun 29.
4
Comparison of disc diffusion, Etest and broth microdilution for testing susceptibility of carbapenem-resistant P. aeruginosa to polymyxins.纸片扩散法、Etest法和肉汤微量稀释法检测耐碳青霉烯类铜绿假单胞菌对多黏菌素敏感性的比较。
Ann Clin Microbiol Antimicrob. 2007 Aug 15;6:8. doi: 10.1186/1476-0711-6-8.
5
Colistin and Polymyxin B Susceptibility Testing for Carbapenem-Resistant and -Positive Enterobacteriaceae: Comparison of Sensititre, MicroScan, Vitek 2, and Etest with Broth Microdilution.耐碳青霉烯类和产碳青霉烯酶肠杆菌科细菌的黏菌素和多黏菌素B敏感性检测：Sensititre、MicroScan、Vitek 2和Etest与肉汤微量稀释法的比较
J Clin Microbiol. 2017 Sep;55(9):2609-2616. doi: 10.1128/JCM.00268-17. Epub 2017 Jun 7.
6
Global assessment of the antimicrobial activity of polymyxin B against 54 731 clinical isolates of Gram-negative bacilli: report from the SENTRY antimicrobial surveillance programme (2001-2004).多粘菌素B对54731株革兰氏阴性杆菌临床分离株抗菌活性的全球评估：哨兵抗菌监测计划（2001 - 2004年）报告
Clin Microbiol Infect. 2006 Apr;12(4):315-21. doi: 10.1111/j.1469-0691.2005.01351.x.
7
Use of a surfactant (polysorbate 80) to improve MIC susceptibility testing results for polymyxin B and colistin.使用表面活性剂（聚山梨酯 80）改善多黏菌素 B 和黏菌素的 MIC 药敏试验结果。
Diagn Microbiol Infect Dis. 2012 Dec;74(4):412-4. doi: 10.1016/j.diagmicrobio.2012.08.025. Epub 2012 Oct 25.
8
Comparison of antibacterial activities of polymyxin B and colistin against multidrug resistant Gram negative bacteria.比较多黏菌素 B 和黏菌素对多重耐药革兰氏阴性菌的抗菌活性。
Infect Dis (Lond). 2019 Sep;51(9):676-682. doi: 10.1080/23744235.2019.1640386. Epub 2019 Jul 12.
9
Antimicrobial activity of the novel polymyxin derivative NAB739 tested against Gram-negative pathogens.新型多粘菌素衍生物 NAB739 对革兰氏阴性病原体的抗菌活性研究。
J Antimicrob Chemother. 2013 Mar;68(3):636-9. doi: 10.1093/jac/dks438. Epub 2012 Nov 6.
10
Activity of polymyxin B and the novel polymyxin analogue CB-182,804 against contemporary Gram-negative pathogens in New York City.在纽约市，多粘菌素 B 和新型多粘菌素类似物 CB-182,804 对当代革兰氏阴性病原体的活性。
Microb Drug Resist. 2012 Apr;18(2):132-6. doi: 10.1089/mdr.2011.0163. Epub 2011 Dec 23.

引用本文的文献

1
Population pharmacokinetics study on nebulized and intravenous administration of polymyxin B in patients with pneumonia caused by multidrug-resistant gram-negative bacteria.多药耐药革兰阴性菌所致肺炎患者雾化吸入与静脉注射多黏菌素B的群体药代动力学研究
Antimicrob Agents Chemother. 2025 May 7;69(5):e0004425. doi: 10.1128/aac.00044-25. Epub 2025 Apr 16.
2
Population Pharmacokinetics of Colistin Sulfate in Critically Ill Patients: Exposure and Clinical Efficacy.硫酸黏菌素在重症患者中的群体药代动力学：暴露量与临床疗效
Front Pharmacol. 2022 Jun 16;13:915958. doi: 10.3389/fphar.2022.915958. eCollection 2022.
3
Manual Reading of Sensititre Broth Microdilution System Panels Improves Accuracy of Susceptibility Reporting for Polymyxin Antibiotics.
手工阅读 Sensititre 肉汤微量稀释系统板可提高多粘菌素类抗生素药敏报告的准确性。
J Clin Microbiol. 2021 Aug 18;59(9):e0033221. doi: 10.1128/JCM.00332-21.
4
Polymyxin Susceptibility Testing and Interpretive Breakpoints: Recommendations from the United States Committee on Antimicrobial Susceptibility Testing (USCAST).多粘菌素药敏试验和解释性折点：美国抗菌药物敏感性试验委员会（USCAST）的建议。
Antimicrob Agents Chemother. 2020 Jan 27;64(2). doi: 10.1128/AAC.01495-19.
5
Polymyxins and Their Potential Next Generation as Therapeutic Antibiotics.多粘菌素及其作为治疗性抗生素的潜在下一代产品
Front Microbiol. 2019 Jul 25;10:1689. doi: 10.3389/fmicb.2019.01689. eCollection 2019.
6
International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti-infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP).多黏菌素优化使用国际共识指南：获得美国临床药师协会（ACCP）、欧洲临床微生物学和传染病学会（ESCMID）、美国感染病学会（IDSA）、国际抗感染药理学会（ISAP）、重症医学学会（SCCM）和感染病药师学会（SIDP）认可。
Pharmacotherapy. 2019 Jan;39(1):10-39. doi: 10.1002/phar.2209.
7
The Search for a Practical Method for Colistin Susceptibility Testing: Have We Found It by Going Back to the Future?寻找一种实用的多粘菌素药敏试验方法：我们是否通过回到未来找到了它？
J Clin Microbiol. 2019 Jan 30;57(2). doi: 10.1128/JCM.01608-18. Print 2019 Feb.
8
in Singapore: Hypervirulent Infections and the Carbapenemase Threat.在新加坡：超级毒力感染和碳青霉烯酶威胁。
Front Cell Infect Microbiol. 2017 Dec 12;7:515. doi: 10.3389/fcimb.2017.00515. eCollection 2017.
9
Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models.系统给予多粘菌素 B 在小鼠大腿和肺部感染模型中针对肺炎克雷伯菌的药代动力学/药效学。
J Antimicrob Chemother. 2018 Feb 1;73(2):462-468. doi: 10.1093/jac/dkx409.
10
Susceptibility Testing for the Polymyxins: Two Steps Back, Three Steps Forward?多粘菌素药敏试验：是后退两步，前进三步？
J Clin Microbiol. 2017 Sep;55(9):2573-2582. doi: 10.1128/JCM.00888-17. Epub 2017 Jul 19.