Liu Ting, Hu Jiang, Li Jia-Xun, Chen Ming-Wei
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Department of General Practice, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China.
J Asian Nat Prod Res. 2020 Aug;22(8):724-731. doi: 10.1080/10286020.2019.1621851. Epub 2019 Jun 1.
Three new monoterpenoid indole alkaloids, kopsiaofficines A-D (), were isolated from the 95% EtOH extract of the aerial parts of . Their structures were established on the basis of spectroscopic data. The isolated alkaloids were tested for cytotoxic activity against seven lung cancer cell lines. Consequently, alkaloids and exhibited some cytotoxic activities against all the tested tumor cell lines with IC values less than 20 µM.[Formula: see text].
从[植物名称]地上部分的95%乙醇提取物中分离出三种新的单萜吲哚生物碱，柯普斯碱A-D（[具体结构公式]）。它们的结构基于光谱数据得以确定。对分离出的生物碱针对七种肺癌细胞系进行了细胞毒性活性测试。结果，生物碱[具体名称]和[具体名称]对所有测试的肿瘤细胞系均表现出一定的细胞毒性活性，其半数抑制浓度（IC）值小于20μM。[公式：见原文] 。
