Rodriguez-Jimenez R, Dompablo M, Bagney A, Santabárbara J, Aparicio A I, Torio I, Moreno-Ortega M, Lopez-Anton R, Lobo A, Kern R S, Green M F, Jimenez-Arriero M A, Santos J L, Nuechterlein K H, Palomo T
Department of Psychiatry, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Department of Psychiatry,Universidad Complutense de Madrid, Spain.
Department of Psychiatry, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Schizophr Res. 2015 Dec;169(1-3):116-120. doi: 10.1016/j.schres.2015.09.013. Epub 2015 Sep 26.
The MATRICS Consensus Cognitive Battery (MCCB) was administered to 293 schizophrenia outpatients and 210 community residents in Spain. Our first objective was to identify the age- and gender-corrected MCCB cognitive profile of patients with schizophrenia. The profile of schizophrenia patients showed deficits when compared to controls across the seven MCCB domains. Reasoning and Problem Solving and Social Cognition were the least impaired, while Visual Learning and Verbal Learning showed the greatest deficits. Our second objective was to study the effects on cognitive functioning of age and gender, in addition to diagnosis. Diagnosis was found to have the greatest effect on cognition (Cohen's d>0.8 for all MCCB domains); age and gender also had effects on cognitive functioning, although to a lesser degree (with age usually having slightly larger effects than gender). The effects of age were apparent in all domains (with better performance in younger subjects), except for Social Cognition. Gender had effects on Attention/Vigilance, Working Memory, Reasoning and Problem Solving (better performance in males), and Social Cognition (better performance in females). No interaction effects were found between diagnosis and age, or between diagnosis and gender. This lack of interactions suggests that age and gender effects are not different in patients and controls.
MATRICS共识认知成套测验（MCCB）应用于西班牙的293名精神分裂症门诊患者和210名社区居民。我们的首要目标是确定经年龄和性别校正后的精神分裂症患者的MCCB认知概况。与对照组相比，精神分裂症患者在MCCB的七个领域均表现出缺陷。推理与问题解决以及社会认知受损最少，而视觉学习和言语学习表现出最大的缺陷。我们的第二个目标是研究除诊断外，年龄和性别对认知功能的影响。发现诊断对认知的影响最大（所有MCCB领域的Cohen's d>0.8）；年龄和性别也对认知功能有影响，尽管程度较小（年龄的影响通常比性别稍大）。除社会认知外，年龄的影响在所有领域都很明显（年轻受试者表现更好）。性别对注意力/警觉性、工作记忆、推理与问题解决（男性表现更好）以及社会认知（女性表现更好）有影响。未发现诊断与年龄之间或诊断与性别之间存在交互作用。这种缺乏交互作用表明，年龄和性别的影响在患者和对照组中并无差异。
