Joukar Siyavash, Najafipour Hamid, Mirzaeipour Fateme, Nasri Hamidreza, Ahmadi Mahboubeh Yeganeh Haj, Badinloo Marziyeh
Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran ; Department of Physiology and Pharmacology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran ; Department of Cardiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
EXCLI J. 2013 Feb 19;12:122-9. eCollection 2013.
Administration of semelil (ANGIPARS™) has been successful in the treatment of diabetic foot ulcer. Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) induced myocardial injury. Animal groups included: control group; ISO group, received ISO 50 mg/kg s.c. for two consecutive days; S1+ISO, S5+ISO and S10+ISO groups, received semelil 1, 5, and 10 mg/kg/day i.p. respectively, 30 min before ISO. On the 3(rd) day, electrocardiogram (ECG) and hemodynamic parameters were recorded; blood samples were taken and hearts were removed for lab investigations. ISO induced heart injury, ECG disturbance, raise of cardiac troponin I and significant decrease in LVSP (p<0.05), +dp/dt max (p<0.01), -dp/dt max (p<0.05) along with increase of LVEDP (p<0.01). Semelil had no significant effects on ECG and plasma cardiac troponin I. Impairment of +dp/dt max and -dp/dt max was significantly improved in S5+ISO and S10+ISO groups (P<0.05 versus ISO). In addition, LVSP and LVEDP was somewhat recovered in these groups, although semelil (1 mg/kg/day) to some extent exacerbated the myocardial lesions induced by ISO (P<0.05). Therefore, in stressful conditions, semelil may improve myocardial contractility; however, it may aggravate the severity of injury.
使用塞梅利（ANGIPARS™）治疗糖尿病足溃疡已取得成功。鉴于该药物具有改善血流和抗炎作用，我们研究了其对异丙肾上腺素（ISO）诱导的兔心肌损伤的心血管性能的影响。动物分组包括：对照组；ISO组，连续两天皮下注射50 mg/kg ISO；S1+ISO、S5+ISO和S10+ISO组，在注射ISO前30分钟分别腹腔注射1、5和10 mg/kg/天的塞梅利。在第3天，记录心电图（ECG）和血流动力学参数；采集血样并取出心脏进行实验室检查。ISO导致心脏损伤、心电图紊乱、心肌肌钙蛋白I升高，左心室收缩压（LVSP）显著降低（p<0.05）、+dp/dt max显著降低（p<0.01）、-dp/dt max显著降低（p<0.05），同时左心室舒张末压（LVEDP）升高（p<0.01）。塞梅利对心电图和血浆心肌肌钙蛋白I无显著影响。S5+ISO组和S10+ISO组+dp/dt max和-dp/dt max的损伤得到显著改善（与ISO组相比，P<0.05）。此外，这些组的LVSP和LVEDP有所恢复，尽管塞梅利（1 mg/kg/天）在一定程度上加重了ISO诱导的心肌损伤（P<0.05）。因此，在应激条件下，塞梅利可能改善心肌收缩力；然而，它可能会加重损伤的严重程度。
