Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
J Physiol Biochem. 2012 Jun;68(2):271-9. doi: 10.1007/s13105-011-0141-z. Epub 2012 Jan 7.
The present study was designed to elucidate the outcome of subchronic co-administration of black tea and nicotine on cardiovascular performance and whether these substances could modulate the isoproterenol-induced cardiac injury. Animal groups were control, black tea, nicotine and black tea plus nicotine. Test groups received nicotine (2 mg/kg s.c.) and black tea brewed (p.o.) each alone and in combination for 4 weeks. On the 28th day, myocardial damage was induced by isoproterenol (50 mg/kg i.p.), and blood samples were taken. On day 29, after hemodynamic parameters recording, hearts were removed for histopathological evaluation. Tea or nicotine consumption had no significant effects on hemodynamic indices of animals without heart damage. When the cardiac injury was induced, tea consumption maintained the maximum dp/dt, and nicotine significantly decreased the pressure-rate product. Moreover, severity of heart lesions was lower in the presence of nicotine or black tea. Concomitant use of these materials did not show extra effects on mentioned parameters more than the effect of each of them alone. The results suggest that subchronic administration of black tea or nicotine for a period of 4 weeks may have a mild cardioprotective effect, while concomitant use of these materials cannot intensify this beneficial effect.
本研究旨在阐明慢性共给予红茶和尼古丁对心血管功能的影响，以及这些物质是否能调节异丙肾上腺素引起的心脏损伤。动物分为对照组、红茶组、尼古丁组和红茶加尼古丁组。实验组每天给予尼古丁（2mg/kg 皮下注射）和红茶（灌胃），单独和联合使用 4 周。第 28 天，用异丙肾上腺素（50mg/kg 腹腔注射）诱导心肌损伤，采集血液样本。第 29 天，记录血流动力学参数后，取出心脏进行组织病理学评估。在没有心脏损伤的动物中，茶或尼古丁的消耗对血流动力学指数没有显著影响。当诱导心脏损伤时，茶的消耗维持最大 dp/dt，而尼古丁显著降低压力-速率乘积。此外，在存在尼古丁或红茶的情况下，心脏病变的严重程度较低。这些物质的同时使用并没有比它们各自的单独使用产生更多的额外效果。结果表明，慢性给予红茶或尼古丁 4 周可能具有轻度的心脏保护作用，而同时使用这些物质不能增强这种有益作用。
