Kumari Avnesh, Singla Rubbel, Guliani Anika, Yadav Sudesh Kumar
Biotechnology Division, CSIR - Institute of Himalayan Bioresource Technology, Palampur-176061 (H.P.), India.
Biotechnology Division, CSIR - Institute of Himalayan Bioresource Technology, Palampur-176061 (H.P.), India ; Academy of Scientific and Innovative Research, New Delhi, India.
EXCLI J. 2014 Mar 20;13:265-86. eCollection 2014.
Nanoencapsulation of drug/small molecules in nanocarriers (NCs) is a very promising approach for development of nanomedicine. Modern drug encapsulation methods allow efficient loading of drug molecules inside the NCs thereby reducing systemic toxicity associated with drugs. Targeting of NCs can enhance the accumulation of nanonencapsulated drug at the diseased site. This article focussed on the synthesis methods, drug loading, drug release mechanism and cellular response of nanoencapsulated drugs on liposomes, micelles, carbon nanotubes, dendrimers, and magnetic NCs. Also the uses of these various NCs have been highlighted in the field of nanotechnology.
将药物/小分子包裹于纳米载体（NCs）中是纳米医学发展中一种非常有前景的方法。现代药物包裹方法能够将药物分子高效载入NCs内部，从而降低与药物相关的全身毒性。NCs的靶向性可增强纳米包裹药物在病变部位的蓄积。本文聚焦于脂质体、胶束、碳纳米管、树枝状大分子和磁性NCs等纳米包裹药物的合成方法、载药情况、药物释放机制及细胞反应。此外，还着重介绍了这些不同NCs在纳米技术领域的应用。
