Felnerova Diana, Viret Jean-François, Glück Reinhard, Moser Christian
Berna Biotech Ltd, Rehhagstrasse 79, CH-3018, Berne, Switzerland.
Curr Opin Biotechnol. 2004 Dec;15(6):518-29. doi: 10.1016/j.copbio.2004.10.005.
Lipid-based vesicles are a very promising approach to treat diseases such as cancer, chronic infections and auto-immunity. Modern drug encapsulation methods allow efficient packing of therapeutic substances inside liposomes, thereby reducing the systemic toxicity of the drugs. Specific targeting can enhance the therapeutic effect of the drugs through their accumulation at the diseased site. In the vaccine field, the integration of functional viral envelope proteins into liposomes has led to an antigen carrier and delivery system termed a virosome, a clinically proven vaccine platform for subunit vaccines with an excellent immunogenicity and tolerability profile.
基于脂质的囊泡是治疗癌症、慢性感染和自身免疫等疾病的一种非常有前景的方法。现代药物封装方法可将治疗物质有效地包裹在脂质体内，从而降低药物的全身毒性。特异性靶向可通过药物在病变部位的积累来增强其治疗效果。在疫苗领域，将功能性病毒包膜蛋白整合到脂质体中已形成一种称为病毒体的抗原载体和递送系统，这是一种临床验证的亚单位疫苗平台，具有出色的免疫原性和耐受性。
