针刺过程中脑灌注不足的光声成像
Photoacoustic imaging of cerebral hypoperfusion during acupuncture.
作者信息
Chen B Z, Yang J G, Wu D, Zeng D W, Yi Y, Yang N, Jiang H B
机构信息
School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Institute of Laboratory Animals of Sichuan Academy of Medical Sciences and Sichuan Province People's Hospital, Chengdu, 610054, China.
出版信息
Biomed Opt Express. 2015 Aug 5;6(9):3225-34. doi: 10.1364/BOE.6.003225. eCollection 2015 Sep 1.
Using acupuncture to treat cerebral hypoperfusion is a hot topic. However, there is a lack of effective tools to clarify the therapeutic effect of acupuncture on cerebral hypoperfusion. Here, we show in a mouse model of cerebral hypoperfusion that photoacoustic tomography (PAT) can noninvasively image cerebral vasculature and track total hemoglobin (HbT) concentration changes in cerebral hypoperfusion with acupuncture stimulation on the YangLingQuan (GB34) point. We measured the changes of HbT concentration and found that the HbT concentration in hypoperfusion regions was clearly lower than that in the control regions when the acupuncture was absent; however, it was significantly increased when the acupuncture was implemented on the GB34 point. We also observed the increase of vessel size and the generation of new vessels in cerebral hypoperfusion during acupuncture. Laser speckle imaging (LSI) was employed to validate some of the PAT findings.
运用针灸治疗脑灌注不足是一个热门话题。然而，目前缺乏有效的工具来阐明针灸对脑灌注不足的治疗效果。在此，我们在脑灌注不足的小鼠模型中表明，光声断层扫描（PAT）能够对脑血管系统进行无创成像，并通过针刺阳陵泉（GB34）穴来追踪脑灌注不足时全血红蛋白（HbT）浓度的变化。我们测量了HbT浓度的变化，发现针刺未进行时，灌注不足区域的HbT浓度明显低于对照区域；然而，当在GB34穴实施针刺时，HbT浓度显著增加。我们还观察到针刺过程中脑灌注不足区域血管尺寸增大以及新血管生成。采用激光散斑成像（LSI）对部分PAT研究结果进行验证。
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