Xiang Li, You Tao, Chen Jianchang, Xu Weiting, Jiao Yang
Department of Cardiology, The Second Affiliated Hospital, Soochow University, Suzhou, Jiangsu, China (mainland).
Med Sci Monit. 2015 Sep 29;21:2912-7. doi: 10.12659/MSM.895441.
The aim of this study was to evaluate the serum soluble semaphorin 4D (sSema4D) in patients with atrial fibrillation and to investigate the relationship of serum sSema4D with left atrial diameter (LAD).
We studied a total of 113 patients who were subdivided into paroxysmal and non-paroxysmal (included persistent and permanent) atrial fibrillation groups, respectively. Another 55 subjects without atrial fibrillation were enrolled as the healthy control group. Serum levels of soluble semaphorin 4D (Sema4D) were measured in all subjects using the enzyme-labeled immunosorbent assay method. We also evaluated the coagulation parameters and left atrial diameters.
Patients with paroxysmal and non-paroxysmal atrial fibrillation had significantly higher sSema4D level compared with controls (8.50±2.19 ng/mL and 9.30±2.28 ng/mL vs. 6.56±1.27 ng/ml, P<0.05). Serum sSema4D concentrations were elevated in patients with non-paroxysmal atrial fibrillation compared to those with paroxysmal atrial fibrillation (P<0.001). The level of sSema4D was positively correlated with LAD (r=0.606, P<0.001). Multivariate logistic regression analysis revealed that serum sSema4D, LAD, male sex, heart rate, hypertension, and coronary artery disease were associated with atrial fibrillation (P<0.05).
Serum sSema4D levels are increased in patients with atrial fibrillation and are independently associated with atrial remodeling.
本研究旨在评估心房颤动患者血清可溶性信号素4D（sSema4D）水平，并探讨血清sSema4D与左心房直径（LAD）的关系。
我们共研究了113例患者，分别分为阵发性心房颤动组和非阵发性（包括持续性和永久性）心房颤动组。另外55例无心房颤动的受试者作为健康对照组。采用酶联免疫吸附测定法测量所有受试者血清可溶性信号素4D（Sema4D）水平。我们还评估了凝血参数和左心房直径。
阵发性和非阵发性心房颤动患者的sSema4D水平显著高于对照组（8.50±2.19 ng/mL和9.30±2.28 ng/mL vs. 6.56±1.27 ng/ml，P<0.05）。与阵发性心房颤动患者相比，非阵发性心房颤动患者血清sSema4D浓度升高（P<0.001）。sSema4D水平与LAD呈正相关（r=0.606，P<0.001）。多因素逻辑回归分析显示，血清sSema4D、LAD、男性、心率、高血压和冠状动脉疾病与心房颤动相关（P<0.05）。
心房颤动患者血清sSema4D水平升高，且与心房重构独立相关。
