细胞可塑性在组织修复中的作用：适应性细胞重编程。

The Role of Cell Plasticity in Tissue Repair: Adaptive Cellular Reprogramming.

机构信息

Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.

出版信息

Dev Cell. 2015 Sep 28;34(6):613-20. doi: 10.1016/j.devcel.2015.09.005.

DOI:10.1016/j.devcel.2015.09.005

Abstract

It is becoming clear that a radical change of cell identity of differentiated cells in vivo, triggered by injury or other adversity, provides an essential route to recovery for many different mammalian tissues. This process, which we term adaptive cellular reprogramming, promotes regeneration in one of two ways: by providing a transient class of repair cells or by directly replacing cells lost during tissue damage. Controlling adaptive changes in cell fate in vivo in order to promote the body's own cell therapy, particularly by pharmacology rather than genetics, is likely to become an increasingly active area of future work.

摘要

很明显，由损伤或其他逆境引发的体内分化细胞的身份的根本改变，为许多不同的哺乳动物组织的恢复提供了一个重要途径。我们将这个过程称为适应性细胞重编程，它通过提供一类短暂的修复细胞或直接替换组织损伤过程中丢失的细胞来促进再生。控制体内细胞命运的适应性变化以促进身体自身的细胞治疗，特别是通过药理学而不是遗传学，可能成为未来工作中越来越活跃的领域。