Lu Yanfeng, Mantha Satya Nymisha, Crowder Douglas C, Chinchilla Sofia, Shah Kush N, Yun Yang H, Wicker Ryan B, Choi Jae-Won
Department of Mechanical Engineering, The University of Akron, Akron, OH 44325, USA.
Biofabrication. 2015 Sep 29;7(4):045001. doi: 10.1088/1758-5090/7/4/045001.
Drug-loaded microneedle arrays for transdermal delivery of a chemotherapeutic drug were fabricated using multi-material microstereolithography (μSL). These arrays consisted of twenty-five poly(propylene fumarate) (PPF) microneedles, which were precisely orientated on the same polymeric substrate. To control the viscosity and improve the mechanical properties of the PPF, diethyl fumarate (DEF) was mixed with the polymer. Dacarbazine, which is widely used for skin cancer, was uniformly blended into the PPF/DEF solution prior to crosslinking. Each microneedle has a cylindrical base with a height of 700 μm and a conical tip with a height of 300 μm. Compression test results and characterization of the elastic moduli of the PPF/DEF (50:50) and PPF/drug mixtures indicated that the failure force was much larger than the theoretical skin insertion force. The release kinetics showed that dacarbazine can be released at a controlled rate for five weeks. The results demonstrated that the PPF-based drug-loaded microneedles are a potential method to treat skin carcinomas. In addition, μSL is an attractive manufacturing technique for biomedical applications, especially for micron-scale manufacturing.
采用多材料微立体光刻技术（μSL）制备了用于经皮递送化疗药物的载药微针阵列。这些阵列由25根聚富马酸丙二醇酯（PPF）微针组成，它们精确地排列在同一聚合物基底上。为了控制PPF的粘度并改善其机械性能，将富马酸二乙酯（DEF）与聚合物混合。在交联之前，将广泛用于皮肤癌治疗的达卡巴嗪均匀地混入PPF/DEF溶液中。每根微针都有一个高度为700μm的圆柱形基部和一个高度为300μm的圆锥形尖端。PPF/DEF（50:50）和PPF/药物混合物的压缩测试结果以及弹性模量表征表明，破坏力远大于理论皮肤插入力。释放动力学表明，达卡巴嗪可以以可控的速率释放五周。结果表明，基于PPF的载药微针是一种治疗皮肤癌的潜在方法。此外，μSL是一种有吸引力的生物医学应用制造技术，特别是对于微米级制造。
