Andrich Silke, Haastert Burkhard, Neuhaus Elke, Neidert Kathrin, Arend Werner, Ohmann Christian, Grebe Jürgen, Vogt Andreas, Jungbluth Pascal, Rösler Grit, Windolf Joachim, Icks Andrea
Department of Public Health, Faculty of Medicine, Heinrich-Heine University, Düsseldorf, Germany.
Department of Public Health, Faculty of Medicine, Heinrich-Heine University, Düsseldorf, Germany; mediStatistica, Neuenrade, Germany.
PLoS One. 2015 Sep 29;10(9):e0139078. doi: 10.1371/journal.pone.0139078. eCollection 2015.
Epidemiological data about pelvic fractures are limited. Until today, most studies only analyzed inpatient data. The purpose of this study was to estimate incidence rates of pelvic fractures in the German population aged 60 years or older, based on outpatient and inpatient data. We conducted a retrospective population-based observational study based on routine data from a large health insurance company in Germany. Age and sex-specific incidence rates of first fractures between 2008 and 2011 were calculated. We also standardized incidence rates with respect to age and sex in the German population. Multiple Poisson regression models were used to evaluate the association between the risk of first pelvic fracture as outcome and sex, age, calendar year and region as independent variables. The total number of patients with a first pelvic fracture corresponded to 8,041 and during the study period 5,978 insured persons needed inpatient treatment. Overall, the standardized incidence rate of all first pelvic fractures was 22.4 [95% CI 22.0-22.9] per 10,000 person-years, and the standardized incidence rate of inpatient treated fractures 16.5 [16.1-16.9]. Our adjusted regression analysis confirmed a significant sex (RR 2.38 [2.23-2.55], p < 0.001, men as reference) and age effect (higher risk with increasing age, p < 0.001) on first fracture risk. We found a slight association between calendar year (higher risk in later years compared to 2008, p = 0.0162) and first fracture risk and a further significant association with region (RR 0.92 [0.87-0.98], p = 0.006, Westfalen-Lippe as reference). The observed incidences are considerably higher than incidences described in the international literature, even if only inpatient treated pelvic fractures are regarded. Besides which, non-inclusion of outpatient data means that a relevant proportion of pelvic fractures are not taken into account. Prevention of low energy trauma among older people remains an important issue.
关于骨盆骨折的流行病学数据有限。直到如今,大多数研究仅分析了住院患者数据。本研究的目的是基于门诊和住院患者数据,估算德国60岁及以上人群中骨盆骨折的发病率。我们基于德国一家大型健康保险公司的常规数据进行了一项基于人群的回顾性观察研究。计算了2008年至2011年间首次骨折的年龄和性别特异性发病率。我们还对德国人群的年龄和性别标准化发病率进行了计算。使用多个泊松回归模型评估首次骨盆骨折风险作为结局与性别、年龄、日历年和地区作为自变量之间的关联。首次发生骨盆骨折的患者总数为8041例,在研究期间,5978名参保人员需要住院治疗。总体而言,所有首次骨盆骨折的标准化发病率为每10000人年22.4[95%可信区间22.0 - 22.9],住院治疗骨折的标准化发病率为16.5[16.1 - 16.9]。我们的校正回归分析证实,性别(相对危险度2.38[2.23 - 2.55],p < 0.001,以男性为参照)和年龄对首次骨折风险有显著影响(随着年龄增长风险升高,p < 0.001)。我们发现日历年与首次骨折风险之间存在轻微关联(与2008年相比,后期年份风险更高,p = 0.0162),并且与地区存在进一步显著关联(相对危险度0.92[0.87 - 0.98],p = 0.006,以威斯特法伦 - 利珀为参照)。即使仅考虑住院治疗的骨盆骨折,观察到的发病率也显著高于国际文献中描述的发病率。此外,未纳入门诊数据意味着相当一部分骨盆骨折未被考虑在内。预防老年人的低能量创伤仍然是一个重要问题。