Liu Yanjun, Zhou Qingxin, Zhao Yanlei, Wang Yiming, Wang Yuming, Wang Jingfeng, Xu Jie, Xue Changhu
College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, 266003, Qingdao, Shandong Province, China.
Biol Trace Elem Res. 2016 May;171(1):167-75. doi: 10.1007/s12011-015-0517-y. Epub 2015 Sep 29.
Sea cucumbers are a potential source of natural organic vanadium that may improve insulin resistance. In this work, vanadium was accumulated rapidly in blood, body wall, and intestine by sea cucumber Apostichopus japonicus. Furthermore, water-soluble vanadium-containing proteins, the main form of the organic vanadium, were tentatively accumulated and isolated by a bioaccumulation experiment. It was also designed to evaluate the beneficial effect of vanadium-containing proteins (VCPs) from sea cucumber rich in vanadium on the development of hyperglycemia and insulin resistance in C57BL/6J mice fed with a high-fat high-sucrose diet (HFSD). HFSD mice treated with VCPs significantly decreased fasting blood glucose, serum insulin, and HOMA-IR values as compared to HFSD mice, respectively. Serum adiponectin, resistin, TNF-α, and leptin levels in insulin-resistant mice were dramatically reduced by a VCP supplement. These results show an ameliorative effect on insulin resistance by treatment with VCPs. Such compound seems to be a valuable therapy to achieve and/or maintain glycemic control and therapeutic agents in the treatment arsenal for insulin resistance and type 2 diabetes.
海参是天然有机钒的潜在来源，可能改善胰岛素抵抗。在这项研究中，海参刺参能迅速在血液、体壁和肠道中积累钒。此外，通过生物积累实验初步积累并分离出了有机钒的主要形式——水溶性含钒蛋白。本研究还旨在评估富含钒的海参含钒蛋白（VCPs）对喂食高脂高糖饮食（HFSD）的C57BL/6J小鼠高血糖和胰岛素抵抗发展的有益作用。与HFSD小鼠相比，用VCPs治疗的HFSD小鼠空腹血糖、血清胰岛素和HOMA-IR值分别显著降低。补充VCP可显著降低胰岛素抵抗小鼠的血清脂联素、抵抗素、TNF-α和瘦素水平。这些结果表明VCPs治疗对胰岛素抵抗有改善作用。这种化合物似乎是实现和/或维持血糖控制的一种有价值的疗法，也是胰岛素抵抗和2型糖尿病治疗药物库中的治疗剂。
