俄罗斯族人群中FOXC2基因附近多态性与静脉曲张风险的关联
Association of polymorphisms near the FOXC2 gene with the risk of varicose veins in ethnic Russians.
作者信息
Shadrina Alexandra S, Smetanina Mariya A, Sokolova Ekaterina A, Sevost'ianova Kseniya S, Shevela Andrey I, Demekhova Marina Y, Shonov Oleg A, Ilyukhin Evgenii A, Voronina Elena N, Zolotukhin Igor A, Kirienko Alexander I, Filipenko Maxim L
机构信息
Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, Russia
Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.
出版信息
Phlebology. 2016 Oct;31(9):640-8. doi: 10.1177/0268355515607404. Epub 2015 Sep 28.
OBJECTIVE
To investigate the association of polymorphisms located near the FOXC2 gene with the risk of varicose veins in ethnic Russians.
METHODS
Allele, genotype, and haplotype frequencies were determined in the sample of 474 patients with primary varicose veins and in the control group of 478 individuals without a history of chronic venous disease.
RESULTS
Polymorphisms rs7189489, rs4633732, and rs1035550 showed the association with the increased risk of varicose veins, but none of the observed associations remained significant after correction for multiple testing. Haplotype analysis revealed the association of haplotype rs7189489 C-rs4633732 T-rs34221221 C-rs1035550 C-rs34152738 T-rs12711457 G with the increased risk of varicose veins (OR = 2.67, P = 0.01).
CONCLUSIONS
Our results provide evidence that the studied polymorphisms do not play a major role in susceptibility to varicose veins development in the Russian population.
目的
研究俄罗斯族人群中FOXC2基因附近的多态性与静脉曲张风险的关联。
方法
在474例原发性静脉曲张患者样本以及478例无慢性静脉疾病病史个体的对照组中，测定等位基因、基因型和单倍型频率。
结果
多态性位点rs7189489、rs4633732和rs1035550显示与静脉曲张风险增加有关，但在多重检验校正后，观察到的关联均无统计学意义。单倍型分析显示单倍型rs7189489 C-rs4633732 T-rs34221221 C-rs1035550 C-rs34152738 T-rs12711457 G与静脉曲张风险增加有关（OR = 2.67，P = 0.01）。
结论
我们的结果表明，所研究的多态性在俄罗斯人群静脉曲张易感性中不起主要作用。
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