Egawa-Takata Tomomi, Ueda Yutaka, Morimoto Akiko, Yoshino Kiyoshi, Kimura Tadashi, Nishikawa Nobumichi, Sekine Masayuki, Horikoshi Yorihiko, Takagi Tetsu, Enomoto Takayuki
The Obstetrical Gynecological Society of Osaka, Osaka, Japan.
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
J Obstet Gynaecol Res. 2015 Dec;41(12):1965-71. doi: 10.1111/jog.12822. Epub 2015 Sep 30.
Following media reports of adverse medical events surrounding human papillomavirus (HPV) vaccination and the suspension of Japanese governmental recommendation, most adolescents have refrained from receiving the vaccine. This represents a national critical event, because the incidence of cervical cancer in Japan continues to increase.
We conducted an Internet survey to investigate why Japanese adolescent girls decline, continue or discontinue their HPV vaccination, how their mothers influence their decision, and the mothers' feelings about future HPV vaccination for their daughters. One thousand mothers with daughters 10-18 years of age were recruited for our questionnaire.
Our results suggest that acceptance of the HPV vaccine was determined predominantly by the mother's perceptions of risk versus benefits, rather than the daughter's wishes. The mothers' knowledge of the benefits of the prophylactic HPV vaccine and their attitude toward cervical cancer screening influenced their decision whether to allow their daughter to receive future vaccinations. The tenor of survey responses of those mothers who were anti-vaccine changed significantly to the positive in response to a proposed scenario where the governmental recommendation for the HPV vaccine was reinstated, whereas a hypothetical educational intervention sheet did not significantly change their attitude.
Promotion of the HPV vaccine through comprehensive education for both mothers and daughters, not only on the vaccine itself, but also about cervical cancer and screening, is required for any successful program to prevent cervical cancer.
继媒体报道人乳头瘤病毒（HPV）疫苗接种引发的不良医疗事件以及日本政府暂停相关建议后，大多数青少年都不再接种该疫苗。这成为了一个全国性的重大事件，因为日本宫颈癌的发病率持续上升。
我们开展了一项网络调查，以探究日本青春期少女拒绝、继续或停止接种HPV疫苗的原因，她们的母亲如何影响她们的决定，以及母亲们对女儿未来接种HPV疫苗的看法。我们招募了1000名女儿年龄在10至18岁之间的母亲参与问卷调查。
我们的结果表明，HPV疫苗的接受度主要取决于母亲对风险与益处的认知，而非女儿的意愿。母亲对预防性HPV疫苗益处的了解以及她们对宫颈癌筛查的态度，影响了她们是否允许女儿未来接种疫苗的决定。那些反对接种疫苗的母亲，在政府恢复HPV疫苗接种建议的假设情景下，其调查反馈的基调显著转向积极，而一份假设的教育干预资料并未显著改变她们的态度。
要成功开展预防宫颈癌的项目，需要通过对母亲和女儿进行全面教育来推广HPV疫苗，不仅要教育她们了解疫苗本身，还要了解宫颈癌及筛查相关知识。
