Frohnert Brigitte I, Rewers Marian J
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO, 80045, USA.
Pediatr Diabetes. 2016 Feb;17(1):3-14. doi: 10.1111/pedi.12323. Epub 2015 Sep 30.
Recent increases in the incidence of both type 1 (T1D) and type 2 diabetes (T2D) in children and adolescents point to the importance of environmental factors in the development of these diseases. Metabolomic analysis explores the integrated response of the organism to environmental changes. Metabolic profiling can identify biomarkers that are predictive of disease incidence and development, potentially providing insight into disease pathogenesis. This review provides an overview of the role of metabolomic analysis in diabetes research and summarizes recent research relating to the development of T1D and T2D in children.
近年来，儿童和青少年中1型糖尿病（T1D）和2型糖尿病（T2D）的发病率均有所上升，这表明环境因素在这些疾病发生发展过程中具有重要作用。代谢组学分析探索生物体对环境变化的综合反应。代谢谱分析能够识别可预测疾病发病率和发展的生物标志物，有可能为疾病发病机制提供深入了解。本综述概述了代谢组学分析在糖尿病研究中的作用，并总结了近期有关儿童T1D和T2D发生发展的研究。
