ABO血型对食管癌手术患者预后的影响。
Impact of ABO blood group on the prognosis of patients undergoing surgery for esophageal cancer.
作者信息
Wang Wei, Liu Lei, Wang Zhiwei, Wei Min, He Qi, Ling Tianlong, Cao Ziang, Zhang Yixin, Wang Qiang, Shi Minxin
机构信息
Department of Surgery, The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China.
Department of Breast, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China.
出版信息
BMC Surg. 2015 Sep 29;15:106. doi: 10.1186/s12893-015-0094-1.
BACKGROUND
ABO blood type is an established prognostic factor in several malignancies, but its role in esophageal cancer (EC) is largely unknown. The aim of this study is to determine whether ABO blood group is associated with survival after esophagectomy for EC.
METHODS
A total of 406 patients who underwent surgery for EC were enrolled. The associations of ABO blood group with clinical and pathological variables were assessed using chi-square test. Associations of ABO blood group with the survival were estimated using univariable and multivariable Cox proportional hazards regression models.
RESULTS
The ABO blood group proportionally associated with the grade of EC tumor (P = 0.049). The ABO blood group status did not correlate with disease-free survival (DFS) in univariable analysis or multivariable analysis (P > 0.05). And there was no significant relationship between the ABO blood group and overall survival (OS) in univariable analysis or multivariable analysis (P > 0.05).
CONCLUSIONS
Our results suggested that no association between ABO blood group and the survival was observed in patients undergoing surgery for EC.
背景
ABO血型是几种恶性肿瘤中已确定的预后因素，但其在食管癌（EC）中的作用尚不清楚。本研究旨在确定ABO血型是否与食管癌切除术后的生存相关。
方法
共纳入406例接受食管癌手术的患者。采用卡方检验评估ABO血型与临床和病理变量的相关性。使用单变量和多变量Cox比例风险回归模型估计ABO血型与生存的相关性。
结果
ABO血型与食管癌肿瘤分级呈比例相关（P = 0.049）。在单变量分析或多变量分析中，ABO血型状态与无病生存期（DFS）均无相关性（P > 0.
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