Furzer Bonnie J, Ackland Timothy R, Wallman Karen E, Petterson Anna S, Gordon Sandy M, Wright Kemi E, Joske David J L
University of Western Australia, M408, 35 Stirling Hwy, Crawley, WA, 6009, Australia.
SolarisCare Foundation Collaborative Research Team, PO Box 7144, Shenton Park, WA, 6008, Australia.
Support Care Cancer. 2016 Apr;24(4):1697-707. doi: 10.1007/s00520-015-2955-7. Epub 2015 Sep 30.
Following treatment, haematological cancer (HEM) patients exhibit significant physical deconditioning and psychological distress. Exercise has been shown as a clinically effective and safe intervention for cancer patients, with the potential to reverse the deleterious effects following treatment. Our aim was to investigate the efficacy of a 12-week exercise rehabilitation on cancer-related fatigue (CRF) and associated outcomes in HEM patients post-treatment.
Patients with a HEM were recruited to participate in a 12-week exercise rehabilitation intervention post-treatment. Pre-, post- and follow-up assessments were conducted on outcome measures including CRF, quality of life (QoL), psychological distress, cardiovascular fitness, muscle strength (MS) and body composition. Patients were given tailored exercise programmes comprising aerobic and resistance exercises, carried out three times per week for 12 weeks in local gyms and clinics. Usual-care participants were offered a delayed, tailored 12-week exercise intervention after the initial study period.
Thirty-seven patients (49 % recruitment rate) were randomly assigned to the 12-week exercise rehabilitation (n = 18) or usual care (n = 19) with a 91 % adherence to the exercise intervention. Following the exercise programme, significant improvements were seen in CRF (p = 0.01), cardiovascular fitness (p ≤ 0.001), QoL (p ≤ 0.001), MS (p ≤ 0.001) and body composition (p = 0.001), with moderate to large effects for all primary outcomes. Patient follow-up at 24 weeks demonstrated outcome maintenance in the exercise rehabilitation group and significant improvements in outcomes in usual-care patients following participation in a delayed exercise programme. There were no adverse reactions or study withdrawals.
A 12-week exercise rehabilitation programme resulted in significant statistical (p ≤ 0.05) and clinical improvements in CRF and additional outcomes in HEM patients following treatment. Additionally, a 12-week delayed exercise programme showed similar significant improvements in patient outcomes.
Australian New Zealand Clinical Trials Registry ACTRN12609000450213.
血液系统癌症（HEM）患者在接受治疗后会出现明显的身体机能下降和心理困扰。运动已被证明是一种对癌症患者临床有效且安全的干预措施，有可能逆转治疗后的有害影响。我们的目的是研究为期12周的运动康复对HEM患者治疗后癌症相关疲劳（CRF）及相关结局的疗效。
招募HEM患者参与治疗后的为期12周的运动康复干预。对包括CRF、生活质量（QoL）、心理困扰、心血管健康、肌肉力量（MS）和身体成分在内的结局指标进行治疗前、治疗后及随访评估。患者接受了包括有氧运动和抗阻运动的量身定制的运动计划，在当地健身房和诊所每周进行三次，共12周。常规护理参与者在初始研究期后接受延迟的、量身定制的12周运动干预。
37名患者（招募率49%）被随机分配至为期12周的运动康复组（n = 18）或常规护理组（n = 19），运动干预的依从率为91%。运动计划实施后，CRF（p = 0.01）、心血管健康（p≤0.001）、QoL（p≤0.001）、MS（p≤0.001）和身体成分（p = 0.001）均有显著改善，所有主要结局的效应为中度至高度。运动康复组在24周时的患者随访显示结局得以维持，常规护理患者在参与延迟运动计划后结局有显著改善。未出现不良反应或研究退出情况。
为期12周的运动康复计划使HEM患者治疗后的CRF及其他结局在统计学上（p≤0.05）和临床上有显著改善。此外，为期12周的延迟运动计划在患者结局方面也显示出类似的显著改善。
澳大利亚新西兰临床试验注册中心ACTRN12609000450213。
