Lor Yer, Revak Andrew, Weigand Jenna, Hicks Elisabeth, Howard David R, King-Heiden Tisha C
Department of Biology, University of Wisconsin La Crosse, La Crosse, WI, United States.
Department of Biology, University of Wisconsin La Crosse, La Crosse, WI, United States.
Reprod Toxicol. 2015 Dec;58:111-8. doi: 10.1016/j.reprotox.2015.09.003. Epub 2015 Sep 28.
Exposure to endocrine disruptors during critical periods of development can impact the sustainability of wild fish populations. Anti-androgenic compounds have received less attention, but are capable of modulating gonad differentiation and maturation, and impairing reproduction in fish. The fungicide vinclozolin (VZ) has been shown to impair reproduction in adult fish, but less is known about its effects following exposure earlier in development. Here we show that waterborne exposure to 400μg VZ/L during critical periods of sex differentiation (21-35 days post fertilization) permanently shifts sex ratios towards females, and alters the maturation of the gonad. Both fecundity and fertility were reduced, even when oogenesis and spermatogenesis recover and sperm motility is not altered. These results demonstrate the need to better understand the impacts of early exposure to anti-androgenic compounds on fish.
在发育的关键时期接触内分泌干扰物会影响野生鱼类种群的可持续性。抗雄激素化合物受到的关注较少，但能够调节性腺分化和成熟，并损害鱼类的繁殖能力。已表明杀菌剂乙烯菌核利（VZ）会损害成年鱼类的繁殖能力，但对于其在发育早期暴露后的影响了解较少。在此我们表明，在性别分化的关键时期（受精后21 - 35天）通过水体接触400μg VZ/L会使性别比例永久性地偏向雌性，并改变性腺的成熟。即使卵子发生和精子发生恢复且精子活力未改变，繁殖力和生育力也会降低。这些结果表明有必要更好地了解早期接触抗雄激素化合物对鱼类的影响。
