来自弗瑞德（Friend）细胞的多聚腺苷酸化和非多聚腺苷酸化核RNA中前体信使RNA序列的频率分布。
Frequency distribution of pre-messenger RNA sequences in polyadenylated and non-polyadenylated nuclear RNA from Friend cells.
作者信息
Balmain A, Minty A J, Birnie G D
出版信息
Nucleic Acids Res. 1980 Apr 11;8(7):1643-60. doi: 10.1093/nar/8.7.1643.
Abstract
Hybridisation of cDNA probes for abundant and rare polysomal polyadenylated RNAs with polyadenylated and non-polyadenylated nuclear RNA from Friend cells indicated that the abundant polysomal polyadenylated RNA sequences were present at a higher concentration in the nucleus than rare polysomal sequences, but at a reduced range of concentrations. The ratio of the concentrations of abundant and rare sequences was about 3 in non-polyadenylated nuclear RNA, 9 in polyadenylated nuclear RNA and 13 in polysomal polyadenylated RNA. This suggests that polyadenylation may play a role in the quantitative selection of sequences for transport to the cytoplasm. Polyadenylation cannot be the only signal for transport, since a highly complex population of nucleus-confined polyadenylated molecules exists, each of which is present on average at less than one copy per cell.
摘要
用来自Friend细胞的多聚腺苷酸化和非多聚腺苷酸化核RNA，对丰富和稀少的多核糖体多聚腺苷酸化RNA的cDNA探针进行杂交，结果表明，丰富的多核糖体多聚腺苷酸化RNA序列在细胞核中的浓度高于稀少的多核糖体序列，但浓度范围有所降低。丰富和稀少序列的浓度比在非多聚腺苷酸化核RNA中约为3，在多聚腺苷酸化核RNA中约为9，在多核糖体多聚腺苷酸化RNA中约为13。这表明多聚腺苷酸化可能在序列向细胞质转运的定量选择中起作用。多聚腺苷酸化不可能是转运的唯一信号，因为存在大量高度复杂的细胞核内多聚腺苷酸化分子群体，每个细胞中平均每个分子的拷贝数不到一个。
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