Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Department of Preventive Medicine, Faculty of Public Health, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; Institute of Health Research, Faculty of Public Health, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Medicina (Kaunas). 2015;51(4):201-8. doi: 10.1016/j.medici.2015.06.006. Epub 2015 Aug 1.
Health-related quality of life (HRQOL) is an important health indicator in medical outcome research and clinical practice. This issue tends to attract even more attention with the recent improvements of patient survival after liver transplantation. This review article aims at providing a deeper insight into practices used for evaluating HRQOL in chronic liver diseases (CLDs) and especially cirrhosis patients during different stages of the disease including liver transplantation.
A systematic review of the MEDLINE database and Cochrane library was conducted. A search using the Medical Subject Headings (MeSH) major terms "liver disease" AND "quality of life" was applied for the period from 1966 to 2012.
Our review identified 1483 publications. The searched showed that significant increase of publications (from 362 to 1018) was observed during last decade (period 2003-2012) in comparison with previous. The majority of publications were in English (n=1179). The literature search and analysis provided information on the most common generic and disease-specific HRQOL instruments, which are used in CLD patients: Medical Outcomes Study Short Form-36, the National Institute of Diabetes and Digestive and Kidney Diseases Quality of Life questionnaire, the Chronic Liver Disease questionnaire, the Liver Disease Quality of Life questionnaire, and other.
Quality of life instruments are potentially powerful tools for evaluating the functional status, presenting gains of treatment and reflecting patients' ability to return to a normal lifestyle in CLD patients. More attention should be paid by clinicians for integrated use of clinical tests together with HRQOL instruments in liver transplantation for establishing the reference levels of mental, physical, and role-social functioning.
健康相关生活质量（HRQOL）是医学结局研究和临床实践中的一个重要健康指标。随着肝移植后患者生存的改善，这一问题受到了更多的关注。本文旨在深入了解用于评估慢性肝病（CLD）患者，特别是肝硬化患者在疾病不同阶段（包括肝移植）的 HRQOL 的实践。
对 MEDLINE 数据库和 Cochrane 图书馆进行了系统的检索。使用医学主题词（MeSH）主要术语“肝病”和“生活质量”进行了 1966 年至 2012 年期间的检索。
我们的检索共识别出 1483 篇文献。与之前相比，在过去十年（2003-2012 年）观察到出版物数量显著增加（从 362 篇增加到 1018 篇）。大多数出版物为英文（n=1179）。文献检索和分析提供了用于 CLD 患者的最常见通用和疾病特异性 HRQOL 工具的信息：健康调查简表-36、国家糖尿病、消化和肾脏疾病质量生活问卷、慢性肝病问卷、肝病生活质量问卷等。
生活质量量表是评估 CLD 患者功能状态、反映治疗效果和患者恢复正常生活能力的潜在有力工具。临床医生应更加关注将临床检查与 HRQOL 量表相结合，在肝移植中建立心理、身体和角色-社会功能的参考水平。
