Yao Bin, Huang Sha, Gao Dongyun, Xie Jiangfan, Liu Nanbo, Fu Xiaobing
Key Laboratory of Wound Repair and Regeneration of PLA, The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P. R. China.
School of Medicine, Nankai University, Tianjin, China.
Int Wound J. 2016 Dec;13(6):1252-1259. doi: 10.1111/iwj.12491. Epub 2015 Oct 1.
Mesenchymal stem cells (MSCs) represent an ideal source of autologous cell-based therapy for chronic wounds. Functional characteristics of MSCs may benefit wound healing by exerting their multi-regenerative potential. However, cell ageing resulting from chronic degenerative diseases or donor age could cause inevitable effects on the regenerative abilities of MSCs. A variety of studies have shown the relationship between MSC ageing and age-related dysfunction, but few associate these age-related impacts on MSCs with their ability of repairing chronic wounds, which are common in the elderly population. Here, we discuss the age-associated changes of MSCs and describe the potential impacts on MSC-based therapy for chronic wounds. Furthermore, critical evaluation of the current literatures is necessary for understanding the underlying mechanisms of MSC ageing and raising the corresponding concerns on considering their possible use for chronic wound repair.
间充质干细胞（MSCs）是慢性伤口自体细胞疗法的理想来源。MSCs的功能特性可通过发挥其多向再生潜能促进伤口愈合。然而，慢性退行性疾病或供体年龄导致的细胞衰老会对MSCs的再生能力产生不可避免的影响。多项研究表明了MSCs衰老与年龄相关功能障碍之间的关系，但很少将这些与年龄相关的对MSCs的影响与其修复慢性伤口的能力联系起来，而慢性伤口在老年人群中很常见。在此，我们讨论MSCs与年龄相关的变化，并描述其对基于MSCs的慢性伤口治疗的潜在影响。此外，对当前文献进行批判性评估对于理解MSCs衰老的潜在机制以及在考虑其用于慢性伤口修复的可能性时提出相应的担忧是必要的。
