Fast D J, Schlievert P M, Nelson R D
Department of Microbiology, University of Minnesota, Minneapolis 55455.
Infect Immun. 1989 Jan;57(1):291-4. doi: 10.1128/iai.57.1.291-294.1989.
Toxic shock syndrome-associated staphylococcal and streptococcal exotoxins were tested for an ability to induce the production of tumor necrosis factor (TNF). Staphylococcal enterotoxins B and C1, along with streptococcal pyrogenic exotoxin A, all induced TNF production in a dose-dependent manner, with production peaking on the average at 3 days but continuing over the 6 days tested. This time course of exotoxin-induced TNF production contrasts with the 1-day peak-2-day duration observed with endotoxin as the stimulus and may be significant to development of toxic shock syndrome.
对与中毒性休克综合征相关的葡萄球菌和链球菌外毒素诱导肿瘤坏死因子（TNF）产生的能力进行了检测。葡萄球菌肠毒素B和C1以及链球菌致热外毒素A均以剂量依赖性方式诱导TNF产生，产生量平均在3天达到峰值，但在测试的6天内持续存在。外毒素诱导TNF产生的这一过程与以内毒素为刺激物观察到的1天峰值-2天持续时间形成对比，这可能对中毒性休克综合征的发展具有重要意义。
