ANARCI：抗原受体编号与受体分类
ANARCI: antigen receptor numbering and receptor classification.
作者信息
Dunbar James, Deane Charlotte M
机构信息
Department of Statistics, Oxford University, Oxford, UK.
出版信息
Bioinformatics. 2016 Jan 15;32(2):298-300. doi: 10.1093/bioinformatics/btv552. Epub 2015 Sep 30.
MOTIVATION
Antibody amino-acid sequences can be numbered to identify equivalent positions. Such annotations are valuable for antibody sequence comparison, protein structure modelling and engineering. Multiple different numbering schemes exist, they vary in the nomenclature they use to annotate residue positions, their definitions of position equivalence and their popularity within different scientific disciplines. However, currently no publicly available software exists that can apply all the most widely used schemes or for which an executable can be obtained under an open license.
RESULTS
ANARCI is a tool to classify and number antibody and T-cell receptor amino-acid variable domain sequences. It can annotate sequences with the five most popular numbering schemes: Kabat, Chothia, Enhanced Chothia, IMGT and AHo.
AVAILABILITY AND IMPLEMENTATION
ANARCI is available for download under GPLv3 license at opig.stats.ox.ac.uk/webapps/anarci. A web-interface to the program is available at the same address.
CONTACT
动机
抗体氨基酸序列可以进行编号以识别等效位置。此类注释对于抗体序列比较、蛋白质结构建模和工程设计很有价值。存在多种不同的编号方案，它们在用于注释残基位置的命名法、位置等效性的定义以及在不同科学学科中的普及程度方面各不相同。然而，目前没有公开可用的软件能够应用所有最广泛使用的方案，也没有可以根据开放许可获得可执行文件的软件。
结果
ANARCI是一种对抗体和T细胞受体氨基酸可变域序列进行分类和编号的工具。它可以用五种最流行的编号方案注释序列：卡巴特（Kabat）、乔西亚（Chothia）、增强型乔西亚（Enhanced Chothia）、国际免疫基因组学数据库（IMGT）和AHo。
可用性和实现方式
ANARCI可根据GPLv3许可在opig.stats.ox.ac.uk/webapps/anarci下载。该程序的网络界面可在同一地址获取。
联系方式
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