Vedak Tejal Kanhaiya, Ganwir Vaishali, Shah Arun B, Pinto Charles, Lele Vikram R, Subramanyam Alka, Shah Hina, Deo Sudha Shrikant
Ph.D. Student, Applied Biology (Immunology), Sir H. N. Medical Research Society and Sir H. N. Reliance Foundation Hospital and Research Centre, Girgaum, Mumbai, Maharashtra, India.
Clinical Psychologist, Sir H. N. Medical Research Society and Sir H. N. Reliance Foundation Hospital and Research Centre, Girgaum, Mumbai, Maharashtra, India.
Ann Indian Acad Neurol. 2015 Jul-Sep;18(3):314-9. doi: 10.4103/0972-2327.160052.
Very few studies in India have addressed the role of vitamin D in cognitive function. The present study was conducted to assess the serum levels of 25-hydroxyvitamin D (25(OH)D) and its association with markers of cognitive impairment and homocysteine levels in the elderly Indian population.
The study population consisted of patients with dementia (Group A, n = 32), mild cognitive impairment (MCI; Group B, n = 24), and elderly age-matched controls (Group C, n = 30). Measurement of serum levels of 25(OH)D and total homocysteine were done.
Significant decreased concentration of 25(OH)D and increased concentration of homocysteine was observed. Association of serum levels of vitamin D with markers of cognitive decline as well as serum homocysteine levels was observed in patients with dementia and MCI when compared to controls.
Correlation of vitamin D with markers of cognitive decline and homocysteine opens a new door for early diagnosis of cognitive impairment.
印度很少有研究探讨维生素D在认知功能中的作用。本研究旨在评估印度老年人群血清25-羟基维生素D（25(OH)D）水平及其与认知障碍标志物和同型半胱氨酸水平的关联。
研究人群包括痴呆患者（A组，n = 32）、轻度认知障碍（MCI；B组，n = 24）和年龄匹配的老年对照组（C组，n = 30）。测定血清25(OH)D和总同型半胱氨酸水平。
观察到25(OH)D浓度显著降低，同型半胱氨酸浓度升高。与对照组相比，痴呆和MCI患者中观察到维生素D血清水平与认知衰退标志物以及血清同型半胱氨酸水平之间的关联。
维生素D与认知衰退标志物和同型半胱氨酸的相关性为认知障碍的早期诊断打开了一扇新的大门。
