Malik Arif, Saleem Shamaila, Basit Ashraf Muhammad Abdul, Qazi Mahmood Husain
Dr. Arif Malik, PhD, Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan.
Dr. Shamaila Saleem, MBBS, M.Phil, Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan.
Pak J Med Sci. 2016 Nov-Dec;32(6):1370-1374. doi: 10.12669/pjms.326.11157.
The present study was designed to assess the role of vitamin-D, in the development of autoimmune thyroid dysfunction in newly diagnosed schizophrenics.
For the present study 100 patients and 100 controls were screened out and studied for their thyroid antibodies, GSH, homocysteine, NOS and vitamin D levels by appropriate protocols to assess the underlying mechanism involved in the schizophrenics susceptible to autoimmune thyroid diseases.
The results of the present study depicted that in schizophrenics, levels of cytokines like IL-6 (7.98±0.67 pg/ml), TNF-α, (40.76±6.98 pg/ml), homocysteine (16.98±1.09 µmol/L), Tg-Ab (30.93±3.87 IU/L), TPO-Ab (10.33±1.78 IU/L) and TSHr-Ab (3.76±0.055 IU/L) increased whereas, those of Vit-D (12.76±0.99 pmol/L), NOS (5.99±0.87 IU/L), GSH (4.48±.965 µg/dl) and NO (16.87±3.98 ng/ml) were decreased in the patients as compared to healthy control subjects.
Vitamin-D in schizophrenia is involved in augmentation of hyperhomocysteinemia, inflammation, oxidative stress and thyroid antibodies, thereby playing a significant role not only in induction of schizophrenic symptoms but may also result in autoimmune thyroid diseases. Thus, earlier detection and rectification of its levels are helpful to limit the miseries of schizophrenia.
本研究旨在评估维生素D在新诊断精神分裂症患者自身免疫性甲状腺功能障碍发展中的作用。
在本研究中，筛选出100例患者和100例对照，通过适当方案检测他们的甲状腺抗体、谷胱甘肽（GSH）、同型半胱氨酸、一氧化氮合酶（NOS）和维生素D水平，以评估精神分裂症患者易患自身免疫性甲状腺疾病的潜在机制。
本研究结果表明，与健康对照相比，精神分裂症患者中白细胞介素-6（IL-6，7.98±0.67 pg/ml）、肿瘤坏死因子-α（TNF-α，40.76±6.98 pg/ml）、同型半胱氨酸（16.98±1.09 μmol/L）、甲状腺球蛋白抗体（Tg-Ab，30.93±3.87 IU/L）、甲状腺过氧化物酶抗体（TPO-Ab，10.33±1.78 IU/L）和促甲状腺素受体抗体（TSHr-Ab，3.76±0.055 IU/L）水平升高，而维生素D（12.76±0.99 pmol/L）、NOS（5.99±0.87 IU/L）、GSH（4.48±0.965 μg/dl）和一氧化氮（NO，16.87±3.98 ng/ml）水平降低。
精神分裂症中的维生素D与高同型半胱氨酸血症、炎症、氧化应激及甲状腺抗体增加有关，不仅在精神分裂症症状的诱发中起重要作用，还可能导致自身免疫性甲状腺疾病。因此，早期检测并纠正其水平有助于减轻精神分裂症的痛苦。
