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以格氏反应、费歇尔吲哚合成反应和关环复分解反应为关键步骤，设计并合成含噻吩和吲哚单元的杂化环番。

Design and synthesis of hybrid cyclophanes containing thiophene and indole units via Grignard reaction, Fischer indolization and ring-closing metathesis as key steps.

作者信息

Kotha Sambasivarao, Chinnam Ajay Kumar, Shirbhate Mukesh Eknathrao

机构信息

Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai-400 076, India.

出版信息

Beilstein J Org Chem. 2015 Aug 31;11:1514-1519. doi: 10.3762/bjoc.11.165. eCollection 2015.

DOI:10.3762/bjoc.11.165
PMID:26425209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4578400/
Abstract

We demonstrate a new synthetic strategy to cyclophanes containing thiophene and indole moieties via Grignard addition, Fischer indolization and ring-closing metathesis as key steps.

摘要

我们展示了一种新的合成策略，通过格氏加成、费歇尔吲哚合成和关环复分解作为关键步骤来合成含有噻吩和吲哚部分的环芳。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/4578400/856fd3cc5255/Beilstein_J_Org_Chem-11-1514-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/4578400/f5a10c5afa1f/Beilstein_J_Org_Chem-11-1514-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/4578400/1098389e86a8/Beilstein_J_Org_Chem-11-1514-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/4578400/4a148402778a/Beilstein_J_Org_Chem-11-1514-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/4578400/4bfd5f3ae935/Beilstein_J_Org_Chem-11-1514-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/4578400/0ed52a293d07/Beilstein_J_Org_Chem-11-1514-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/4578400/856fd3cc5255/Beilstein_J_Org_Chem-11-1514-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/4578400/f5a10c5afa1f/Beilstein_J_Org_Chem-11-1514-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/4578400/1098389e86a8/Beilstein_J_Org_Chem-11-1514-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/4578400/4a148402778a/Beilstein_J_Org_Chem-11-1514-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/4578400/4bfd5f3ae935/Beilstein_J_Org_Chem-11-1514-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/4578400/0ed52a293d07/Beilstein_J_Org_Chem-11-1514-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/4578400/856fd3cc5255/Beilstein_J_Org_Chem-11-1514-g007.jpg

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Org Lett. 2012 Sep 7;14(17):4568-71. doi: 10.1021/ol302034r. Epub 2012 Aug 20.
3
Diversity-oriented approach to macrocyclic cyclophane derivatives by Suzuki-Miyaura cross-coupling and olefin metathesis as key steps.
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J Org Chem. 2012 Jan 6;77(1):482-9. doi: 10.1021/jo2020714. Epub 2011 Dec 13.
4
Construction of the cyclophane core of the hirsutellones via a RCM strategy.通过 RCM 策略构建毛喉萜烷的环芳烷核心。
Org Lett. 2010 Jun 4;12(11):2504-7. doi: 10.1021/ol100692x.
5
A retrospective on the design and synthesis of novel molecules through a strategic consideration of metathesis and Suzuki-Miyaura cross-coupling.通过对复分解反应和铃木-宫浦交叉偶联反应的策略性考量对新型分子的设计与合成进行回顾。
Chem Asian J. 2009 Mar 2;4(3):354-62. doi: 10.1002/asia.200800244.
6
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Chemistry. 2008;14(30):9215-22. doi: 10.1002/chem.200800942.
7
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Chemistry. 2008;14(11):3297-305. doi: 10.1002/chem.200701862.
8
Insulated molecular wires.绝缘分子导线
Angew Chem Int Ed Engl. 2007;46(7):1028-64. doi: 10.1002/anie.200601780.
9
The building block approach to unusual alpha-amino acid derivatives and peptides.构建非常规α-氨基酸衍生物和肽的模块法。
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10
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