Uruc Fatih, Urkmez Ahmet, Yuksel Ozgur Haki, Sahin Aytac, Verit Ayhan
Fatih Sultan Mehmet Research and Training Hospital, Department of Urology, Içerenkoy/Atasehir, Istanbul, Turkey.
Can Urol Assoc J. 2015 Sep-Oct;9(9-10):E644-7. doi: 10.5489/cuaj.2867. Epub 2015 Sep 9.
Functional adrenocortical carcinoma (ACC) is a very rare disease with a poor prognosis. Over half (60%) of ACCs bigger than 6 cm synthesize hormones; hormone-secreting ACCs generally include virilization, feminization or Cushing syndrome. Besides, 82% of ACCs are metastatic at the time of diagnosis. While a 48-year-old female patient was examined for abdominal pain and flushing, we detected a non-metastasizing mass (23 × 18 × 16 cm) in the adrenal lodge. The mass was extracted en bloc during open exploration and its histopathology was reported as ACC. We review the literature and report the largest androgen-producing, clinically silent ACC mass cited in the literature so far.
功能性肾上腺皮质癌（ACC）是一种非常罕见的疾病，预后较差。超过一半（60%）直径大于6 cm的ACC会合成激素；分泌激素的ACC通常包括男性化、女性化或库欣综合征。此外，82%的ACC在诊断时已有转移。一名48岁女性患者因腹痛和潮热接受检查时，我们在肾上腺部位发现了一个无转移的肿块（23×18×16 cm）。在开放探查时将肿块整块切除，其组织病理学报告为ACC。我们回顾了文献，并报告了迄今为止文献中所提及的最大的产生雄激素、临床上无症状的ACC肿块。
