Rafizadeh Sassan, Yoneda Ken, Zeki Amir A
University of California, Davis Medical Center, Sacramento, CA, USA.
J Investig Med High Impact Case Rep. 2015 May 19;3(2):2324709615587528. doi: 10.1177/2324709615587528. eCollection 2015 Apr-Jun.
We report a patient with tracheopathia osteoplastica (TPO), a rare or perhaps underrecognized disorder, detected in approximately 1 in every 2000 to 5000 patients who undergo bronchoscopy. TPO is marked by proliferation of bony and cartilaginous spurs leading to airway stenosis. Multiple submucosal cartilaginous and osseous nodules can develop in the respiratory tract and may involve the entire trachea and mainstem bronchi. Symptoms may range from a completely silent condition to life-threatening respiratory failure and diagnosis is made based on radiological and bronchoscopic findings. Although the etiology has not been established, TPO can be familial and is sometimes associated with chronic inflammation, such as seen with rheumatic diseases. This case highlights the need for understanding TPO so that it can be differentiated from potentially serious conditions such as necrotizing granulomatous diseases, invasive infections, and cancer.
我们报告了一例患有骨化性气管病（TPO）的患者，这是一种罕见或可能未被充分认识的疾病，在每2000至5000例接受支气管镜检查的患者中约有1例被检测到。TPO的特征是骨和软骨性骨刺增生，导致气道狭窄。呼吸道可出现多个黏膜下软骨和骨性结节，可累及整个气管和主支气管。症状范围从完全无症状到危及生命的呼吸衰竭，诊断基于影像学和支气管镜检查结果。虽然病因尚未明确，但TPO可能具有家族性，有时与慢性炎症有关，如在风湿性疾病中所见。本病例强调了了解TPO的必要性，以便将其与潜在的严重疾病如坏死性肉芽肿性疾病、侵袭性感染和癌症区分开来。
