呼吸、运动和冥想对炎症性肠病心理和身体症状及炎症生物标志物的影响：一项随机对照试验
The Effect of Breathing, Movement, and Meditation on Psychological and Physical Symptoms and Inflammatory Biomarkers in Inflammatory Bowel Disease: A Randomized Controlled Trial.
作者信息
Gerbarg Patricia L, Jacob Vinita E, Stevens Laurie, Bosworth Brian P, Chabouni Fatiha, DeFilippis Ersilia M, Warren Ryan, Trivellas Myra, Patel Priyanka V, Webb Colleen D, Harbus Michael D, Christos Paul J, Brown Richard P, Scherl Ellen J
机构信息
*Department of Psychiatry, New York Medical College, Valhalla, New York; †Department of Medicine, Division of Gastroenterology and Hepatology, Jill Roberts Center for Inflammatory Bowel Disease, Weill Cornell Medical College, New York, New York; ‡Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York; and §Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, New York.
出版信息
Inflamm Bowel Dis. 2015 Dec;21(12):2886-96. doi: 10.1097/MIB.0000000000000568.
BACKGROUND
This study evaluated the effects of the Breath-Body-Mind Workshop (BBMW) (breathing, movement, and meditation) on psychological and physical symptoms and inflammatory biomarkers in inflammatory bowel disease (IBD).
METHODS
Twenty-nine IBD patients from the Jill Roberts IBD Center were randomized to BBMW or an educational seminar. Beck Anxiety Inventory, Beck Depression Inventory, Brief Symptom Inventory 18, IBD Questionnaire, Perceived Disability Scale, Perceived Stress Questionnaire, Digestive Disease Acceptance Questionnaire, Brief Illness Perception Questionnaire, fecal calprotectin, C-reactive protein, and physiological measures were obtained at baseline and weeks 6 and 26.
RESULTS
The BBMW group significantly improved between baseline and week 6 on Brief Symptom Inventory 18 (P = 0.02), Beck Anxiety Inventory (P = 0.02), and IBD Questionnaire (P = 0.01) and between baseline and week 26 on Brief Symptom Inventory 18 (P = 0.04), Beck Anxiety Inventory (P = 0.03), Beck Depression Inventory (P = 0.01), IBD Questionnaire (P = 0.01), Perceived Disability Scale (P = 0.001), and Perceived Stress Questionnaire (P = 0.01) by paired t tests. No significant changes occurred in the educational seminar group at week 6 or 26. By week 26, median C-reactive protein values decreased significantly in the BBMW group (P = 0.01 by Wilcoxon signed-rank test) versus no significant change in the educational seminar group.
CONCLUSIONS
In patients with IBD, participation in the BBMW was associated with significant improvements in psychological and physical symptoms, quality of life, and C-reactive protein. Mind-body interventions, such as BBMW, which emphasize Voluntarily Regulated Breathing Practices, may have significant long-lasting benefits for IBD symptoms, anxiety, depression, quality of life, and inflammation. BBMW, a promising adjunctive treatment for IBD, warrants further study.
背景
本研究评估了呼吸 - 身体 - 心灵工作坊（BBMW）（呼吸、运动和冥想）对炎症性肠病（IBD）患者心理和身体症状以及炎症生物标志物的影响。
方法
来自吉尔·罗伯茨IBD中心的29名IBD患者被随机分为BBMW组或教育研讨会组。在基线、第6周和第26周时获取贝克焦虑量表、贝克抑郁量表、简明症状量表18、IBD问卷、感知残疾量表、感知压力问卷、消化系统疾病接受问卷、简明疾病感知问卷、粪便钙卫蛋白、C反应蛋白和生理指标。
结果
通过配对t检验，BBMW组在基线至第6周时，简明症状量表18（P = 0.02）、贝克焦虑量表（P = 0.02）和IBD问卷（P = 0.01）有显著改善，在基线至第26周时，简明症状量表18（P = 0.04）、贝克焦虑量表（P = 0.03）、贝克抑郁量表（P = 0.01）、IBD问卷（P = 0.01）、感知残疾量表（P = 0.001）和感知压力问卷（P = 0.01）有显著改善。教育研讨会组在第6周或第26周时无显著变化。到第26周时，BBMW组的C反应蛋白中位数显著下降（威尔科克森符号秩检验，P = 0.01），而教育研讨会组无显著变化。
结论
在IBD患者中，参与BBMW与心理和身体症状（如焦虑、抑郁、生活质量）以及C反应蛋白的显著改善有关。身心干预措施，如BBMW，强调自主调节呼吸练习，可能对IBD症状、焦虑、抑郁、生活质量和炎症有显著的长期益处。BBMW作为一种有前景的IBD辅助治疗方法值得进一步研究。
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