Zhou Mengjiao, Zhang Xiujuan, Yu Caitong, Nan Xueyan, Chen Xianfeng, Zhang Xiaohong
Functional Nano & Soft Materials Laboratory (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology, Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, PR China.
Functional Nano & Soft Materials Laboratory (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology, Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, PR China.
Nanomedicine. 2016 Jan;12(1):181-9. doi: 10.1016/j.nano.2015.09.006. Epub 2015 Sep 30.
In this paper, shape regulated anticancer activities as well as systematic toxicities of hydroxycamptothecin nanorods and nanoparticles (HCPT NRs and NPs) were systematically studied. In vitro and in vivo therapeutic efficacies were evaluated in cancer cells and tumor-bearing mice, indicating that NRs possessed superior antitumor efficacy over NPs at the equivalent dose, while systematic toxicity of the differently shaped nanodrugs assessed in healthy mice, including the maximum tolerated dose, blood analysis and histology examinations and so on, suggested that the NRs also caused higher toxicities than NPs, and also had a long-term toxicity. These results imply that the balance between anticancer efficiency and systematic toxicity of drug nanocrystals should be fully considered in practice, which will provide new concept in the future design of drug nanocrystals for cancer therapy. From the Clinical Editor: Advances in nanotechnology have enabled the design of novel nanosized drugs for the treatment of cancer. One of the interesting findings thus far is the different biological effects seen with different shaped nanoparticles. In this article, the authors investigated and compared the anticancer activities of hydroxycamptothecin nanorods and nanoparticles. The experimental data would provide a better understanding for future drug design.
在本文中，系统研究了羟基喜树碱纳米棒和纳米颗粒（HCPT NRs和NPs）的形状调控抗癌活性以及全身毒性。在癌细胞和荷瘤小鼠中评估了体外和体内治疗效果，表明在等效剂量下，NRs比NPs具有更高的抗肿瘤疗效，而在健康小鼠中评估的不同形状纳米药物的全身毒性，包括最大耐受剂量、血液分析和组织学检查等，表明NRs也比NPs引起更高的毒性，并且具有长期毒性。这些结果意味着在实际应用中应充分考虑药物纳米晶体抗癌效率和全身毒性之间的平衡，这将为未来癌症治疗药物纳米晶体的设计提供新的概念。临床编辑评论：纳米技术的进步使得设计用于治疗癌症的新型纳米药物成为可能。迄今为止，一个有趣的发现是不同形状的纳米颗粒具有不同的生物学效应。在本文中，作者研究并比较了羟基喜树碱纳米棒和纳米颗粒的抗癌活性。实验数据将为未来的药物设计提供更好的理解。
