纳米氧化铈：干性年龄相关性黄斑变性的一种潜在疗法。
Nanoceria: a Potential Therapeutic for Dry AMD.
作者信息
Cai Xue, McGinnis James F
机构信息
Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, 608 Stanton L. Young Blvd, 73104, Oklahoma City, OK, USA.
Department of Ophthalmology, Dean McGee Eye Institute, Department of Cell Biology, Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, 73104, Oklahoma City, OK, USA.
出版信息
Adv Exp Med Biol. 2016;854:111-8. doi: 10.1007/978-3-319-17121-0_16.
Age-related macular degeneration (AMD) is the leading cause of blinding diseases. The "dry" form of AMD is the most common form of AMD. In contrast to the treatable neovascular (wet) AMD, no effective treatment is available for dry AMD. In this review, we summarize the animal models and therapeutic strategies for dry AMD. The novel candidates as potential treatment targets and the potential effectiveness of nanoceria as a treatment of dry AMD are also discussed.
年龄相关性黄斑变性（AMD）是致盲疾病的主要原因。“干性”AMD是AMD最常见的形式。与可治疗的新生血管性（湿性）AMD不同，干性AMD尚无有效的治疗方法。在本综述中，我们总结了干性AMD的动物模型和治疗策略。还讨论了作为潜在治疗靶点的新候选物以及纳米氧化铈治疗干性AMD的潜在有效性。
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