Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Dean McGee Eye Institute, Oklahoma City, OK, USA.
Adv Exp Med Biol. 2018;1074:117-123. doi: 10.1007/978-3-319-75402-4_15.
Over the last few years, huge progress has been made in the understanding of molecular mechanisms underlying the pathogenesis of retinal degenerative diseases. Such knowledge has led to the development of gene therapy approaches to treat these devastating disorders. Non-viral gene delivery has been recognized as a prospective treatment for retinal degenerative diseases. In this review, we will summarize the constituent characteristics and recent applications of three representative nanoparticles (NPs) in ocular therapy.
在过去的几年中，人们对视网膜退行性疾病发病机制的分子机制的理解取得了巨大进展。这些知识导致了基因治疗方法的发展，以治疗这些破坏性疾病。非病毒基因传递已被认为是治疗视网膜退行性疾病的一种有前途的方法。在这篇综述中，我们将总结三种代表性纳米颗粒（NPs）在眼部治疗中的组成特征和最新应用。
