化学诱变筛选鉴定出具有ERG缺陷的小鼠模型。
A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.
作者信息
Charette Jeremy R, Samuels Ivy S, Yu Minzhong, Stone Lisa, Hicks Wanda, Shi Lan Ying, Krebs Mark P, Naggert Jürgen K, Nishina Patsy M, Peachey Neal S
机构信息
The Jackson Laboratory, 04609, Bar Harbor, ME, USA.
Louis Stokes Cleveland VA Medical Center, 44106, Cleveland, OH, USA.
出版信息
Adv Exp Med Biol. 2016;854:177-83. doi: 10.1007/978-3-319-17121-0_24.
Abstract
Mouse models provide important resources for many areas of vision research, pertaining to retinal development, retinal function and retinal disease. The Translational Vision Research Models (TVRM) program uses chemical mutagenesis to generate new mouse models for vision research. In this chapter, we report the identification of mouse models for Grm1, Grk1 and Lrit3. Each of these is characterized by a primary defect in the electroretinogram. All are available without restriction to the research community.
摘要
小鼠模型为视觉研究的许多领域提供了重要资源，涉及视网膜发育、视网膜功能和视网膜疾病。转化视觉研究模型（TVRM）计划利用化学诱变来生成用于视觉研究的新小鼠模型。在本章中，我们报告了Grm1、Grk1和Lrit3小鼠模型的鉴定。这些模型中的每一个都具有视网膜电图的原发性缺陷特征。所有模型均可无限制地提供给研究界。
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本文引用的文献
1
Lrit3 deficient mouse (nob6): a novel model of complete congenital stationary night blindness (cCSNB).Lrit3基因缺陷小鼠（nob6）：一种完全性先天性静止性夜盲（cCSNB）的新型模型。
PLoS One. 2014 Mar 5;9(3):e90342. doi: 10.1371/journal.pone.0090342. eCollection 2014.
2
Mouse b-wave mutants.小鼠b波突变体
Doc Ophthalmol. 2014 Apr;128(2):77-89. doi: 10.1007/s10633-013-9424-8. Epub 2014 Jan 7.
3
Whole-exome sequencing identifies LRIT3 mutations as a cause of autosomal-recessive complete congenital stationary night blindness.全外显子组测序鉴定出 LRIT3 突变是常染色体隐性完全先天性静止性夜盲症的病因。
Am J Hum Genet. 2013 Jan 10;92(1):67-75. doi: 10.1016/j.ajhg.2012.10.023. Epub 2012 Dec 13.
4
Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation.由于 Trpm1 点突变导致去极化双极细胞功能障碍。
J Neurophysiol. 2012 Nov;108(9):2442-51. doi: 10.1152/jn.00137.2012. Epub 2012 Aug 15.
5
Deleterious GRM1 mutations in schizophrenia.精神分裂症中的有害 GRM1 突变。
PLoS One. 2012;7(3):e32849. doi: 10.1371/journal.pone.0032849. Epub 2012 Mar 20.
6
Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia.胱硫醚-β-合酶突变小鼠，高同型半胱氨酸血症模型，视觉功能随年龄变化。
Exp Eye Res. 2012 Mar;96(1):124-31. doi: 10.1016/j.exer.2011.12.011. Epub 2011 Dec 16.
7
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8
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9
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