• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Direct conversion of astrocytes into neuronal cells by drug cocktail.

作者信息

Cheng Lin, Gao Longfei, Guan Wuqiang, Mao Jianxin, Hu Wenxiang, Qiu Binlong, Zhao Jian, Yu Yongchun, Pei Gang

机构信息

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

出版信息

Cell Res. 2015 Nov;25(11):1269-72. doi: 10.1038/cr.2015.120. Epub 2015 Oct 2.

DOI:10.1038/cr.2015.120
PMID:26427716
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4650423/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d68/4650423/ffbf5be5f53d/cr2015120f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d68/4650423/ffbf5be5f53d/cr2015120f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d68/4650423/ffbf5be5f53d/cr2015120f1.jpg

相似文献

1
Direct conversion of astrocytes into neuronal cells by drug cocktail.通过药物组合将星形胶质细胞直接转化为神经元细胞。
Cell Res. 2015 Nov;25(11):1269-72. doi: 10.1038/cr.2015.120. Epub 2015 Oct 2.
2
Generation of neural progenitor cells by chemical cocktails and hypoxia.通过化学鸡尾酒和低氧环境生成神经祖细胞。
Cell Res. 2014 Jun;24(6):665-79. doi: 10.1038/cr.2014.32. Epub 2014 Mar 18.
3
Valproic acid enhances glucose transport in the cultured brain astrocytes of glucose transporter 1 heterozygous mice.丙戊酸可增强葡萄糖转运蛋白1杂合小鼠培养脑星形胶质细胞中的葡萄糖转运。
J Child Neurol. 2013 Jan;28(1):70-6. doi: 10.1177/0883073812440044. Epub 2012 Apr 24.
4
MicroRNA-Mediated In Vitro and In Vivo Direct Conversion of Astrocytes to Neuroblasts.微小RNA介导的星形胶质细胞体外及体内直接转化为神经母细胞
PLoS One. 2015 Jun 1;10(6):e0127878. doi: 10.1371/journal.pone.0127878. eCollection 2015.
5
Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes.丙戊酸盐通过刺激星形胶质细胞释放神经营养因子,保护中脑神经元/神经胶质细胞培养物中的多巴胺能神经元。
Mol Psychiatry. 2006 Dec;11(12):1116-25. doi: 10.1038/sj.mp.4001893. Epub 2006 Sep 12.
6
A chemical approach to "rewire" neural progenitor cells.一种化学方法来“重编”神经祖细胞。
Cell Res. 2014 Jun;24(6):641-2. doi: 10.1038/cr.2014.51. Epub 2014 Apr 18.
7
Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes.丙戊酸通过激活星形胶质细胞释放肿瘤坏死因子-α诱导分化的海马神经元凋亡。
Neurosci Lett. 2011 Jun 22;497(2):122-7. doi: 10.1016/j.neulet.2011.04.044. Epub 2011 Apr 27.
8
In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3.锂抑制糖原合酶激酶-3在大脑中的体内证据。
Neuropsychopharmacology. 2004 Jan;29(1):32-8. doi: 10.1038/sj.npp.1300283.
9
Opposite effects of lithium and valproic acid on trophic factor deprivation-induced glycogen synthase kinase-3 activation, c-Jun expression and neuronal cell death.锂盐和丙戊酸对营养因子剥夺诱导的糖原合酶激酶-3激活、c-Jun表达及神经元细胞死亡的相反作用。
Neuropharmacology. 2005 Mar;48(4):576-83. doi: 10.1016/j.neuropharm.2004.11.010. Epub 2005 Jan 25.
10
In vitro characteristics of valproic acid and all-trans-retinoic acid and their combined use in promoting neuronal differentiation while suppressing astrocytic differentiation in neural stem cells.丙戊酸和全反式维甲酸的体外特性及其联合使用在促进神经干细胞神经元分化同时抑制星形胶质细胞分化方面的作用
Brain Res. 2015 Jan 30;1596:31-47. doi: 10.1016/j.brainres.2014.11.029. Epub 2014 Nov 20.

引用本文的文献

1
Valproic Acid Promotes the Differentiation of Satellite Glial Cells into Neurons via the pH-Dependent Pathway.丙戊酸通过pH依赖性途径促进卫星胶质细胞向神经元分化。
Biomolecules. 2025 Jul 11;15(7):986. doi: 10.3390/biom15070986.
2
BMSC-NFMC Model for Vascular Regulation and Interface Integration in Osteochondral Regeneration.用于骨软骨再生中血管调节和界面整合的骨髓间充质干细胞-纳米纤维微载体复合物模型
Adv Sci (Weinh). 2025 Sep;12(33):e05222. doi: 10.1002/advs.202505222. Epub 2025 Jun 23.
3
Changing genes, cells and networks to reprogram the brain after stroke.

本文引用的文献

1
Direct Conversion of Normal and Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules.小分子将正常和阿尔茨海默病人类成纤维细胞直接转化为神经元细胞。
Cell Stem Cell. 2015 Aug 6;17(2):204-12. doi: 10.1016/j.stem.2015.07.006.
2
Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons.小分子诱导的小鼠成纤维细胞直接重编程为功能性神经元。
Cell Stem Cell. 2015 Aug 6;17(2):195-203. doi: 10.1016/j.stem.2015.06.003.
3
A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse.
改变基因、细胞和神经网络以在中风后重新编程大脑。
Nat Neurosci. 2025 Jun;28(6):1130-1145. doi: 10.1038/s41593-025-01981-8. Epub 2025 Jun 2.
4
Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules.利用强效小分子在体外和体内对人胶质母细胞瘤进行快速有效的神经元转化
Cell Prolif. 2025 Aug;58(8):e70013. doi: 10.1111/cpr.70013. Epub 2025 Mar 11.
5
Single-cell RNA sequencing of neonatal cortical astrocytes reveals versatile cell clusters during astrocyte-neuron conversion.新生儿皮质星形胶质细胞的单细胞RNA测序揭示了星形胶质细胞-神经元转化过程中的多种细胞簇。
Mol Biol Rep. 2025 Feb 3;52(1):189. doi: 10.1007/s11033-025-10309-5.
6
Using Small Molecules to Reprogram RPE Cells in Regenerative Medicine for Degenerative Eye Disease.利用小分子对再生医学中用于退行性眼病的视网膜色素上皮细胞进行重编程。
Cells. 2024 Nov 21;13(23):1931. doi: 10.3390/cells13231931.
7
A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia.一项多重单细胞测序筛选鉴定出可增强小鼠穆勒胶质细胞神经源性重编程的化合物。
Elife. 2024 Dec 12;12:RP92091. doi: 10.7554/eLife.92091.
8
Conversion of glioma cells into neuron-like cells by small molecules.小分子诱导胶质瘤细胞向神经元样细胞的转化
iScience. 2024 Oct 2;27(11):111091. doi: 10.1016/j.isci.2024.111091. eCollection 2024 Nov 15.
9
AI identifies potent inducers of breast cancer stem cell differentiation based on adversarial learning from gene expression data.人工智能基于基因表达数据的对抗学习识别乳腺癌干细胞分化的有效诱导剂。
Brief Bioinform. 2024 Mar 27;25(3). doi: 10.1093/bib/bbae207.
10
Conversion of Astrocyte Cell Lines to Oligodendrocyte Progenitor Cells Using Small Molecules and Transplantation to Animal Model of Multiple Sclerosis.使用小分子将星形胶质细胞系转化为少突胶质前体细胞,并将其移植到多发性硬化症动物模型中。
J Mol Neurosci. 2024 Apr 9;74(2):40. doi: 10.1007/s12031-024-02206-6.
小鼠星形胶质细胞中 Notch 信号调控的潜在神经发生程序。
Science. 2014 Oct 10;346(6206):237-41. doi: 10.1126/science.346.6206.237. Epub 2014 Oct 9.
4
Generation of neural progenitor cells by chemical cocktails and hypoxia.通过化学鸡尾酒和低氧环境生成神经祖细胞。
Cell Res. 2014 Jun;24(6):665-79. doi: 10.1038/cr.2014.32. Epub 2014 Mar 18.
5
Development-inspired reprogramming of the mammalian central nervous system.受发育启发的哺乳动物中枢神经系统重编程。
Science. 2014 Jan 31;343(6170):1239882. doi: 10.1126/science.1239882.
6
In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model.脑损伤和阿尔茨海默病模型中反应性神经胶质细胞在体直接重编程为功能性神经元。
Cell Stem Cell. 2014 Feb 6;14(2):188-202. doi: 10.1016/j.stem.2013.12.001. Epub 2013 Dec 19.
7
In vivo reprogramming of astrocytes to neuroblasts in the adult brain.在成年大脑中将星形胶质细胞重编程为神经前体细胞。
Nat Cell Biol. 2013 Oct;15(10):1164-75. doi: 10.1038/ncb2843. Epub 2013 Sep 22.
8
Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons.小分子使神经基因 2 能够有效地将人成纤维细胞转化为胆碱能神经元。
Nat Commun. 2013;4:2183. doi: 10.1038/ncomms3183.
9
Directing astroglia from the cerebral cortex into subtype specific functional neurons.指导大脑皮层中的星形胶质细胞分化为特定亚型的功能性神经元。
PLoS Biol. 2010 May 18;8(5):e1000373. doi: 10.1371/journal.pbio.1000373.
10
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis.在成体神经发生过程中,Wnt介导的NeuroD1和逆转录元件的激活。
Nat Neurosci. 2009 Sep;12(9):1097-105. doi: 10.1038/nn.2360. Epub 2009 Aug 23.