Erickson Ariane E, Edmondson Dennis, Chang Fei-Chien, Wood Dave, Gong Alex, Levengood Sheeny Lan, Zhang Miqin
Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.
Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.
Carbohydr Polym. 2015 Dec 10;134:467-74. doi: 10.1016/j.carbpol.2015.07.097. Epub 2015 Aug 1.
The inability to produce large quantities of nanofibers has been a primary obstacle in advancement and commercialization of electrospinning technologies, especially when aligned nanofibers are desired. Here, we present a high-throughput centrifugal electrospinning (HTP-CES) system capable of producing a large number of highly-aligned nanofiber samples with high-yield and tunable diameters. The versatility of the design was revealed when bead-less nanofibers were produced from copolymer chitosan/polycaprolactone (C-PCL) solutions despite variations in polymer blend composition or spinneret needle gauge. Compared to conventional electrospinning techniques, fibers spun with the HTP-CES not only exhibited superior alignment, but also better diameter uniformity. Nanofiber alignment was quantified using Fast Fourier Transform (FFT) analysis. In addition, a concave correlation between the needle diameter and resultant fiber diameter was identified. This system can be easily scaled up for industrial production of highly-aligned nanofibers with tunable diameters that can potentially meet the requirements for various engineering and biomedical applications.
无法大量生产纳米纤维一直是静电纺丝技术进步和商业化的主要障碍，尤其是在需要排列整齐的纳米纤维时。在此，我们展示了一种高通量离心静电纺丝（HTP-CES）系统，该系统能够高产且直径可调地生产大量高度排列整齐的纳米纤维样品。当从共聚物壳聚糖/聚己内酯（C-PCL）溶液中生产无珠纳米纤维时，尽管聚合物共混物组成或喷丝头针规有所变化，但该设计的通用性仍得以体现。与传统静电纺丝技术相比，用HTP-CES纺出的纤维不仅排列更优，而且直径均匀性更好。使用快速傅里叶变换（FFT）分析对纳米纤维排列进行了量化。此外，还确定了针直径与所得纤维直径之间的凹面相关性。该系统可以轻松扩大规模，用于工业生产具有可调直径的高度排列整齐的纳米纤维，这些纳米纤维有可能满足各种工程和生物医学应用的要求。
