酿酒酵母转录因子IIIA的纯化与特性分析
Purification and characterization of Saccharomyces cerevisiae transcription factor IIIA.
作者信息
Wang C K, Weil P A
机构信息
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
出版信息
J Biol Chem. 1989 Jan 15;264(2):1092-9.
Saccharomyces cerevisiae Transcription Factor IIIA (TFIIIA) has been purified to apparent homogeneity. Two polypeptides copurified with TFIIIA activity. Yeast TFIIIA is a DNA-binding protein which exhibits a high affinity for the internal control region of the homologous 5 S ribosomal RNA gene. Characterization of the yeast protein indicates that it shares most, but not all, of the molecular properties of its Xenopus TFIIIA counterpart.
酿酒酵母转录因子IIIA（TFIIIA）已被纯化至表观均一。有两种多肽与TFIIIA活性共纯化。酵母TFIIIA是一种DNA结合蛋白，对同源5S核糖体RNA基因的内部控制区域表现出高亲和力。对酵母蛋白的特性分析表明，它与其非洲爪蟾TFIIIA对应物具有大部分但并非全部的分子特性。
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