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2
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Multicenter evaluation of MIC distributions for epidemiologic cutoff value definition to detect amphotericin B, posaconazole, and itraconazole resistance among the most clinically relevant species of Mucorales.多中心评估最小抑菌浓度（MIC）分布以确定流行病学临界值，用于检测毛霉目中最具临床相关性的菌种对两性霉素B、泊沙康唑和伊曲康唑的耐药性。
Antimicrob Agents Chemother. 2015 Mar;59(3):1745-50. doi: 10.1128/AAC.04435-14. Epub 2015 Jan 12.
2
Species distribution and in vitro antifungal susceptibility profiles of yeast isolates from invasive infections during a Portuguese multicenter survey.葡萄牙多中心调查期间侵袭性感染酵母分离株的物种分布及体外抗真菌药敏谱
Eur J Clin Microbiol Infect Dis. 2014 Dec;33(12):2241-7. doi: 10.1007/s10096-014-2194-8. Epub 2014 Jul 11.
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Epidemiology and outcomes of invasive candidiasis due to non-albicans species of Candida in 2,496 patients: data from the Prospective Antifungal Therapy (PATH) registry 2004-2008.2496例非白色念珠菌所致侵袭性念珠菌病的流行病学及转归：来自2004 - 2008年前瞻性抗真菌治疗（PATH）注册研究的数据
PLoS One. 2014 Jul 3;9(7):e101510. doi: 10.1371/journal.pone.0101510. eCollection 2014.
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Candidemia in intensive care unit: a nationwide prospective observational survey (GISIA-3 study) and review of the European literature from 2000 through 2013.重症监护病房的念珠菌血症：一项全国性前瞻性观察性调查（GISIA-3研究）及对2000年至2013年欧洲文献的综述
Eur Rev Med Pharmacol Sci. 2014;18(5):661-74.
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Multilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazole.对八种念珠菌属对氟康唑、泊沙康唑和伏立康唑耐药性检测的流行病学截断值的多实验室研究。
Antimicrob Agents Chemother. 2014;58(4):2006-12. doi: 10.1128/AAC.02615-13. Epub 2014 Jan 13.
6
Multicenter study of anidulafungin and micafungin MIC distributions and epidemiological cutoff values for eight Candida species and the CLSI M27-A3 broth microdilution method.八株念珠菌及 CLSI M27-A3 肉汤微量稀释法的两性霉素 B 及米卡芬净 MIC 分布与流行病学折点的多中心研究
Antimicrob Agents Chemother. 2014;58(2):916-22. doi: 10.1128/AAC.02020-13. Epub 2013 Nov 25.
7
Candida species distribution and antifungal susceptibility testing according to European Committee on Antimicrobial Susceptibility Testing and new vs. old Clinical and Laboratory Standards Institute clinical breakpoints: a 6-year prospective candidaemia survey from the fungal infection network of Switzerland.根据欧洲抗菌药物敏感性试验委员会和新的与旧的临床和实验室标准协会临床折点进行的念珠菌属菌种分布和抗真菌药敏试验：来自瑞士真菌感染网络的 6 年前瞻性念珠菌血症调查。
Clin Microbiol Infect. 2014 Jul;20(7):698-705. doi: 10.1111/1469-0691.12440. Epub 2013 Dec 12.
8
Nosocomial bloodstream infections due to Candida spp. in the USA: species distribution, clinical features and antifungal susceptibilities.美国念珠菌属引起的医院血流感染：菌种分布、临床特征和抗真菌药敏性。
Int J Antimicrob Agents. 2014 Jan;43(1):78-81. doi: 10.1016/j.ijantimicag.2013.09.005. Epub 2013 Oct 12.
9
Interlaboratory variability of Caspofungin MICs for Candida spp. Using CLSI and EUCAST methods: should the clinical laboratory be testing this agent?使用CLSI和EUCAST方法检测念珠菌属对卡泊芬净的最低抑菌浓度（MIC）的实验室间变异性：临床实验室是否应该检测这种药物？
Antimicrob Agents Chemother. 2013 Dec;57(12):5836-42. doi: 10.1128/AAC.01519-13. Epub 2013 Sep 9.
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Epidemiology and outcomes of candidemia in 3648 patients: data from the Prospective Antifungal Therapy (PATH Alliance®) registry, 2004-2008.3648 例念珠菌血症患者的流行病学和结局：来自 2004-2008 年前瞻性抗真菌治疗（PATH 联盟）登记研究的数据。
Diagn Microbiol Infect Dis. 2012 Dec;74(4):323-31. doi: 10.1016/j.diagmicrobio.2012.10.003. Epub 2012 Oct 25.

葡萄牙念珠菌对棘白菌素的最低抑菌浓度升高，但由FKS介导的耐药性罕见。

Candida lusitaniae MICs to the echinocandins are elevated but FKS-mediated resistance is rare.

作者信息

Lockhart Shawn R, Pham Cau D, Kuykendall Randall J, Bolden Carol B, Cleveland Angela A

机构信息

Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.

出版信息

Diagn Microbiol Infect Dis. 2016 Jan;84(1):52-54. doi: 10.1016/j.diagmicrobio.2015.08.012. Epub 2015 Aug 28.

DOI:10.1016/j.diagmicrobio.2015.08.012
PMID:26429293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5939560/
Abstract

MIC values were generated for caspofungin, micafungin, and anidulafungin against 106 isolates of C. lusitaniae, and these values were compared to established epidemiologic cutoff values. The majority of isolates were wild type both by MIC value as well as by FKS1 hotspot sequencing. Although C. lusitaniae isolates have MIC values to the echinocandins that are elevated compared to other common species, with regard to known mechanisms of resistance to the echinocandins, isolates with MIC values at or below the epidemiological cutoff values of 0.5 and 1 μg/mL for micafungin and anidulafungin, respectively, should be considered wild type.

摘要

测定了卡泊芬净、米卡芬净和阿尼芬净对106株葡萄牙念珠菌的最低抑菌浓度（MIC）值，并将这些值与既定的流行病学临界值进行比较。通过MIC值以及FKS1热点测序，大多数分离株为野生型。尽管葡萄牙念珠菌分离株对棘白菌素的MIC值高于其他常见菌种，但就已知的对棘白菌素的耐药机制而言，米卡芬净和阿尼芬净的MIC值分别在0.5和1μg/mL的流行病学临界值及以下的分离株应被视为野生型。